下丘脑神经肽在中枢能量代谢方面的调节作用

The role of hypothalamic neuropeptides in the central nervous system regulation of energy metabolism

摘要:

下丘脑作为调控能量稳态的中枢，在维持机体能量代谢平衡方面发挥重要作用，通过下丘脑弓状核内神经肽Y、Agouti相关蛋白、阿黑皮素原及甘丙肽之间相互作用形成的调节网络控制能量摄入及消耗，维持代谢稳态。但调控网络上任何一个环节产生异常都有可能导致机体能量调节紊乱，最终导致肥胖症。该文主要综述了下丘脑神经肽在中枢能量代谢方面的调控作用，为将来干预和治疗肥胖等内分泌疾病提供依据。

Abstract:

Hypothalamus, as the center of regulating energy homeostasis, plays an important role in maintaining the balance of energy metabolism. The interactions among neuropeptide Y, agouti-related peptide, pro-opiomelanocortin and galanin in the arcuate nucleus of the hypothalamus form a regulatory network that controls the energy intake and consumption and maintains the metabolic homeostasis. The abnormality of any link in the regulatory network may lead to the disorder of systemic energy regulation, which could ultimately be an essential cause for obesity. This review mainly summarizes the role of hypothalamic neuropeptides in the central nervous system regulation of energy metabolism, aiming to provide a basis for future intervention and treatment of obesity and other endocrine diseases.