创新免疫状态评估体系的建立及其在疾病诊疗中的应用

Research progress in novel approaches to immune status evaluation and their application in clinical practice

摘要:

过去几十年，免疫学领域解决了如何抑制免疫力和提高免疫状态的技术积累和突破，随之带来亟需解决的问题是如何评估免疫力，如何建立免疫力评估标准体系，这将是免疫学领域下一个必须攻克的挑战。通过淋巴细胞亚群分析、细胞因子分析和基因水平的检测手段都可能在一定程度上反映个体免疫状态，但是在临床上，这些诊断技术很少能带来实质性的诊断和治疗价值。该文创立了基于阴阳平衡理论指导的分析淋巴细胞亚群的免疫评估和评分体系，不仅能够量化免疫力水平，而且可以指导肝移植患者免疫抑制药物管理，监测肿瘤患者免疫力变化趋势、自身免疫性疾病的诊断等。

Abstract:

In the past few decades, the field of immunology has achieved a breakthrough in technical facets of how to suppress immunity or increase immune status. The subsequent challenges to overcome are how to evaluate the immunity and to establish a standard system for evaluating immunity. Analysis of lymphocyte subsets and cytokines as well as detection means at the gene level may reflect individual immune status to a certain extent, but these techniques are hardly of substantial value for diagnosis and treatment in clinical practice. We have established an immune evaluation method and scoring system for analysis of lymphocyte subsets based on the theory of Yin-Yang balance, which can not only quantify the level of immunity, but also guide the management of immunosuppressive drugs for patients with liver transplantation, monitor the changing trend of immunity for patients with tumors, and facilitate the diagnosis of autoimmune diseases.