带状疱疹患者Treg/Th17与病情严重程度、后遗神经痛持续时间的相关性研究

Correlations between Treg/Th17 and disease severity and duration of postherpetic neuralgia in patients with herpes zoster

摘要:

目的 探讨带状疱疹患者Treg/Th17及其与病情严重程度、后遗神经痛持续时间的相关性。方法 选取2019年8月—2020年8月南通市第二人民医院收治的126例带状疱疹患者为研究对象，收集患者临床资料及治疗前生物化学指标，治疗后随访12个月。对比不同病情程度患者Treg/Th17，分析影响带状疱疹患者病情严重程度的因素，分析Treg/Th17对带状疱疹患者病情严重程度的诊断价值，统计不同病情严重程度带状疱疹患者后遗神经痛持续时间，分析带状疱疹患者Treg/Th17与后遗神经痛持续时间的相关性。结果 轻度组Treg、Treg/Th17均高于中、重度组（P <0.05），Th17低于中、重度组（P <0.05）；中度组Treg、Treg/Th17高于重度组（P <0.05），Th17低于重度组（P <0.05）。多因素Logistic回归分析结果显示：Th17［O^R=3.916（95% CI：1.611，9.516）］、Treg/Th17［O^R=4.289（95% CI：1.765，10.423）］是影响带状疱疹患者病情严重程度的独立因素（P <0.05）。ROC曲线结果显示，Treg/Th17诊断带状疱疹患者重度病情的敏感性为75.00%（95% CI：0.112，0.277）、特异性为81.91%（95% CI：0.121，0.438）、曲线下面积为0.775（95% CI：0.678，0.872）。重度组后遗神经痛持续时间长于轻、中度组（P <0.05），轻、中度组后遗神经痛持续时间比较，差异无统计学意义（P >0.05）。Pearson相关性分析结果显示，带状疱疹患者Treg/Th17与后遗神经痛持续时间呈负相关（r =-0.716，P =0.000）。结论 带状疱疹患者Treg/Th17与病情严重程度及后遗神经痛持续时间有关，Treg/Th17诊断带状疱疹患者病情严重程度效能良好，可作为评估后遗神经痛持续时间的指标。

关键词:带状疱疹;Treg/Th17;病情;后遗神经痛

Abstract:

Objective To explore the correlations between Treg/Th17 level and disease severity and the duration of postherpetic neuralgia in patients with herpes zoster.Methods A total of 126 patients with herpes zoster admitted to Nantong Second People's Hospital from August 2019 to August 2020 were selected. The clinical data and biochemical indicators before the treatment of all patients were collected, and the patients were followed up for 12 months after the treatment. The Treg/Th17 levels in patients with different disease severity were compared. The factors affecting the disease severity of herpes zoster patients were analyzed. The diagnostic value of Treg/Th17 level for the disease severity of herpes zoster patients was determined. The duration of postherpetic neuralgia in herpes zoster patients with different disease severity was observed, and the correlation between Treg/Th17 level and the duration of postherpetic neuralgia in herpes zoster patients was analyzed.Results The levels of Treg and Treg/Th17 in the mild disease group were higher than those in the moderate disease group and the severe disease group (P < 0.05), and the Th17 level in the mild disease group was lower than that in the moderate disease group and the severe disease group (P < 0.05). The levels of Treg and Treg/Th17 in the moderate disease group were higher than those in the severe disease group (P < 0.05), and the Th17 level in the moderate disease group was lower than that in the severe disease group (P < 0.05). The multivariable Logistic regression analysis revealed that Th17 level [O^R = 3.916 (95% CI: 1.611, 9.516) ] and Treg/Th17 level [O^R = 4.289 (95% CI: 1.765, 10.423) ] were independent factors affecting the disease severity of herpes zoster patients (P < 0.05). The ROC curve showed that the sensitivity, specificity, and AUC of Treg/Th17 level for diagnosing the severe disease in herpes zoster patients were 75.00% (95% CI: 0.112, 0.277), 81.91% (95% CI: 0.121, 0.438), and 0.775 (95% CI: 0.678, 0.872), respectively. The duration of postherpetic neuralgia in the severe disease group was longer than that in the mild and moderate disease groups (P < 0.05). There was no difference in the duration of postherpetic neuralgia between the mild and moderate disease groups (P > 0.05). Pearson correlation analysis demonstrated that the Treg/Th17 level was negatively correlated with the duration of postherpetic neuralgia in herpes zoster patients (r = -0.716, P = 0.000).Conclusions The Treg/Th17 level is related to the disease severity and the duration of postherpetic neuralgia in patients with herpes zoster. The Treg/Th17 level is effective in diagnosing the disease severity of herpes zoster patients, and may be considered as an indicator for evaluating the duration of postherpetic neuralgia.

Key words:herpes zoster;Treg/Th17;disease severity;postherpetic neuralgia