2型糖尿病肠黏膜屏障损伤研究及治疗进展

Research progress in the dysfunction of the intestinal mucosal barrier in type 2 diabetes mellitus and its treatment advances

摘要:

2型糖尿病（T2DM）的发病率较高，但其病因和发病机制尚未完全阐明。随着微生态技术的发展，肠道屏障功能与T2DM的联系受到越来越多的关注。肠黏膜屏障在维持机体内环境和抵御外来病原菌入侵等生理功能方面具有重要作用。因此，肠黏膜屏障很可能是治疗T2DM的重要位点，该文将综述肠黏膜屏障损伤在T2DM中的发生、发展及治疗方面的作用，旨在为T2DM的治疗提供新的思路。

Abstract:

The incidence of type 2 diabetes mellitus (T2DM) has been on the rise, yet its etiology and pathogenesis have not been fully elucidated. With the development of intestinal microecology, more and more attentions have been paid to the relationship between the intestinal barrier and T2DM. Intestinal mucosal barrier plays important roles in maintaining the internal homeostasis and defending against the invasion of external pathogens. Thus, this article reviews the roles of the dysfunction of the intestinal mucosal barrier in the occurrence, development and treatment of T2DM, which may provide novel insights for treating T2DM.