Notch信号通路在自身免疫性疾病中的作用机制研究进展

Research progress of Notch signaling pathway in autoimmune diseases

摘要:

Notch信号通路与多种免疫细胞、传导通路、分子等调控机制密切相关。Notch信号通路在包含类风湿性关节炎、系统性红斑狼疮、系统性硬化症、炎症性肠病等多种自身免疫性疾病发生、发展中发挥着至关重要的作用。该文就Notch信号通路的结构与生理学特征、调控功能及其在自身免疫性疾病中的作用进行相关综述。

Abstract:

Notch signaling pathway is closely related to a variety of regulatory mechanisms in the levels of immune cells, signal transduction pathways and molecules. It has been revealed that Notch signaling pathway plays an important role in the occurrence and progression of various autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and inflammatory bowel disease. This review summarizes the composition, physiological characteristics, and regulatory function of Notch signaling pathway and its roles in autoimmune diseases.