微生态制剂联合孟鲁司特钠治疗小儿过敏性紫癜的疗效及其对体液免疫的影响

Effects of microecologics combined with montelukast sodium on therapeutic efficacy and humoral immunity in children with Henoch-Schönlein purpura

摘要:

目的 分析微生态制剂联合孟鲁司特钠治疗小儿过敏性紫癜的疗效及其对患儿体液免疫的影响。方法 选取2019年12月—2020年12月唐山市工人医院90例过敏性紫癜患儿作为研究对象，按照随机数字表法分为对照组与研究组，每组45例。对照组给予孟鲁司特钠治疗，研究组在该基础上予以微生态制剂治疗。比较两组临床疗效、T淋巴细胞、辅助性T淋巴细胞Th1/Th2型细胞因子、体液免疫及不良反应情况。结果 研究组的治疗有效率（97.78%）高于对照组（86.67%）（P <0.05）；治疗后，研究组CD₄⁺比例、CD₄⁺/CD₈⁺高于对照组（P <0.05），CD₈⁺比例低于对照组（P <0.05）；研究组IFN-γ、IL-4、Th1/Th2低于对照组（P <0.05）；研究组IgA低于对照组（P <0.05），两组IgG、IgM比较，差异无统计学意义（P >0.05）；所有患儿治疗期间均未出现明显不良反应。结论 微生态制剂联合孟鲁司特钠治疗小儿过敏性紫癜疗效可观，可有效调节患儿细胞免疫和体液免疫功能，且用药安全性较高。

Abstract:

Objective To analyze the effect of microecological preparation combined with montelukast sodium on children's Henoch-Sch?nlein purpura and humoral immunity.Methods A total of 90 children with Henoch-Sch?nlein purpura from December 2019 to December 2020 were randomly divided into control group and study group with 45 cases in each group. The control group was treated with montelukast sodium and the study group was treated with probiotics. The clinical efficacy, T lymphocyte, T helper t lymphocyte Th1/Th2 cytokines, humoral immunity, and adverse reactions were compared between the two groups.Results After treatment, the effective rate of the study group was 97.78%, which was higher than that in the control group (86.67%) with statistically significant difference (P < 0.05); CD4⁺ and CD4⁺ / CD8⁺ in the study group were higher than those in the control group (P < 0.05); CD8⁺ in the study group was lower than that in the control group (P < 0.05); IFN- γ, IL-4, and Th1 / Th2 in the control group were significantly lower than those in the control group (P < 0.05); there was no significant difference in IgG and IgM between the two groups (P > 0.05). IgA in the study group was lower than that in the control group (P < 0.05); no obvious adverse reactions were observed during the treatment.Conclusion The combination of microecological preparations and montelukast sodium in the treatment of children with allergic purpura can effectively regulate the cellular and humoral immune functions of children, and the medication is safe.