脂联素在衰老和损伤中成骨作用的研究进展及主要困惑探讨

Research progress and related issues on the roles of adiponectin in osteogenesis in the setting of aging and injury

摘要:

脂肪因子脂联素与骨代谢关系密切，并进行了大量的细胞、模型动物及人群的调查研究。虽然许多研究证实了脂联素对成骨的正向调节作用，但是研究结果不完全一致。目前仍未能完全了解脂联素信号通路在年龄、疾病及骨修复中的重要性。该述评探讨了脂联素对成骨作用的初步研究结论，脂联素不同异构体、不同受体的可能作用通路，以及老年人群的脂联素生物学改变。探究脂联素对骨骼生物学的调控作用有助于药物开发和非药物（生活方式）干预方式的研究。针对脂联素信号进行干预，可能有助于维护衰老过程中的骨健康和损伤后的骨骼修复。

Abstract:

Adiponectin is considered to be closely related to bone metabolism and has been extensively investigated in cell and animal models as well as population-based studies. Though a multitude of studies supported the positive role of adiponectin in regulating osteogenesis, these findings are not completely consistent. The roles of adiponectin signaling in aging, diseases and bone regeneration have not been fully unraveled. In this review, we discussed the preliminary results of current studies on the role of adiponectin in osteogenesis, possible pathways of different isomers and receptors of adiponectin, and biological changes of adiponectin in the elderly. Understanding the role of adiponectin in modulating skeletal biology is the key to developing both pharmacological and non-pharmacological (lifestyle) interventions that target adiponectin signaling, which may help keep the bones healthy during aging and facilitate bone repair after injury.