SATB1、CBX7表达预测结直肠癌患者术后复发的价值

Predictive values of SATB1 and CBX7 expressions for postoperative recurrence of colorectal cancer

摘要:

目的 探究核基质结合区结合蛋白1（SATB1）与色素框蛋白7（CBX7）表达预测结直肠癌患者术后复发的价值。方法 回顾性分析2018年4月—2021年2月新疆医科大学第二附属医院收治的104例行结直肠癌根治术患者的临床资料，取其留存的癌组织蜡块进行分析。采用免疫组织化学法检测癌组织SATB1、CBX7的表达，两组患者均随访12个月，按照术后复发、淋巴结远端转移将患者分为复发组和未复发组。采用多因素Logistic回归模型分析结直肠癌术后复发的相关因素。绘制受试者工作特征（ROC）曲线评估SATB1、CBX7表达预测结直肠癌术后复发的价值。结果 104例结直肠癌患者中73例复发，复发率为70.19%。复发组临床分期Ⅲ和Ⅳ期、肿瘤低分化、有淋巴结转移、SATB1阳性表达、CBX7阳性表达、SATB1和CBX7均阳性表达占比均高于未复发组（P <0.05），SATB1、CBX7均阴性表达占比低于未复发组（P <0.05）。多因素Logistic回归分析结果显示，临床分期Ⅲ和Ⅳ期、肿瘤低分化、淋巴结转移、SATB1阳性表达及CBX7阳性表达均为结直肠癌术后复发的危险因素（P <0.05）。ROC曲线结果显示，SATB1阳性、CBX7阳性、SATB1和CBX7均阳性、SATB1和CBX7均阴性预测结直肠癌术后复发的曲线下面积分别为0.640（95% CI：0.524，0.756）、0.659（95% CI：0.546，0.771）、0.739（95% CI：0.641，0.837）和0.743（95% CI：0.633，0.853）。结论 SATB1、CBX7表达预测结直肠癌术后复发效能较高。

Abstract:

Objective To explore the values of special AT-rich binding protein 1 (SATB1) and Chromobox protein homolog 7 (CBX7) expressions in predicting the postoperative recurrence of colorectal cancer.Methods The clinical data and cancer tissues of 104 patients who underwent radical resection of colorectal cancer from April 2018 to February 2021 were retrospectively analyzed. The expressions of SATB1 and CBX7 in the cancer tissues were detected by immunohistochemistry. The patients in both groups were followed up for 12 months and were divided into recurrence group and non-recurrence group based on whether postoperative relapse and lymph node metastasis occurred. The multivariable Logistic regression analysis was performed to determine the factors affecting the postoperative recurrence of colorectal cancer. The area under the receiver operating characteristic (ROC) curve (AUC) was used to evaluate the predictive values of SATB1 and CBX7 expressions for postoperative recurrence of colorectal cancer.Results Among 104 patients with colorectal cancer, 73 cases recurred, with the recurrence rate being 70.19%. The proportions of stage Ⅲ and Ⅳ tumors, poorly-differentiated tumors, lymph node metastasis, positivity for SATB1 expression, positivity for CBX7 expression, and positivity for both SATB1 and CBX7 expressions in the recurrence group were higher than those in the non-recurrence group, while the proportions of negativity for both SATB1 and CBX7 expressions in the recurrence group were lower than those in the non-recurrence group (P < 0.05). The multivariable Logistic regression analysis showed that stage Ⅲ and Ⅳ tumors, poorly-differentiated tumors, lymph node metastasis, positive SATB1 expression and positive CBX7 expression were the risk factors for postoperative recurrence of colorectal cancer (P < 0.05). ROC analysis showed that the AUCs of positivity for SATB1 expression, positivity for CBX7 expression, positivity for both SATB1 and CBX7 expressions and negativity for both SATB1 and CBX7 expressions in predicting the postoperative recurrence of colorectal cancer were 0.640 (95% CI: 0.524, 0.756), 0.659 (95% CI: 0.546, 0.771), 0.739 (95% CI: 0.641, 0.837) and 0.743 (95% CI: 0.633, 0.853), respectively.Conclusions The expressions of SATB1 and CBX7 exhibit high predictive values for the postoperative recurrence of colorectal cancer.