微生态制剂对儿童腹型过敏性紫癜疗效及免疫功能的影响研究

Effects of probiotics on efficacy and immune response of abdominal Henoch Schonlein purpura in children

摘要:

目的 探讨微生态制剂对儿童腹型过敏性紫癜疗效及免疫功能的影响。方法 选取2017年8月—2021年9月海南省第五人民医院收治的腹型过敏性紫癜患儿102例作为研究对象，用随机数字表法分为对照组和研究组，每组51例。对照组采用常规治疗，研究组在对照组基础上辅以微生态制剂（双歧杆菌四联活菌片）治疗。比较两组的临床疗效、症状缓解时间及住院时间、肠道菌群、肠道黏膜屏障功能、免疫功能及不良反应。结果 研究组治疗总有效率为94.12%，对照组为80.39%，研究组高于对照组（P <0.05）。治疗后，研究组腹泻时间、皮疹时间、便血时间、住院时间均短于对照组（P <0.05）；治疗后，研究组乳杆菌、双歧杆菌比对照组高，肠球菌、肠杆菌比对照组低，且治疗前后差值均高于对照组（P <0.05）；治疗后，研究组二胺氧化酶（DAO）、D-乳酸、内毒素水平均比对照组低，且治疗前后差值均高于对照组（P <0.05）；治疗后，研究组免疫球蛋白M（IgM）、免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、调节性T细胞（Treg）、调节性B细胞（Breg）、抑制性细胞（MDSC）均比对照组低，且治疗前后差值均高于对照组（P <0.05）。结论 微生态制剂辅助治疗儿童腹型过敏性紫癜的临床疗效确切，可有效纠正肠道菌群紊乱，改善患儿肠黏膜屏障功能和免疫功能，缓解临床症状。

Abstract:

Objective To investigate the effect of microecological preparation on the efficacy and immune response of abdominal Henoch-Sch?nlein purpura in children.Methods A total of 102 children with abdominal Henoch-Sch?nlein purpura admitted to our hospital from August to September 2017 were divided into control group (51 cases) and study group (51 cases) according to the table of random numbers. The control group was treated with conventional therapy, and the study group was supplemented with microecological preparation (Bifidobacterium quadrilateral viable tablet). The clinical efficacy, symptom relief time, hospital stay, intestinal flora, intestinal mucosal barrier function, and immune response were compared between the two groups.Results The total effective rate of the study group was higher than the control group (P < 0.05). After treatment, the days of diarrhea, skin rash, blood in stool, and hospitalization in the study group were lower than those in the control group (P < 0.05); and the levels of Bifidobacterium and Lactobacillus in the study group were higher than those in the control group, Enterobacteriaceae and Enterococcus were lower than the control group, and the difference before and after treatment was higher than the control group (P < 0.05); and the levels of diamine oxidase, d-lactic acid, and endotoxin in the study group were lower than those in the control group after treatment, the difference before and after treatment was higher than that in the control group (P < 0.05). After treatment, the difference of IgM, IgA, IgG, Treg, Breg, and MDSC in the study group was lower than that in the control group, and the difference before and after treatment was higher than that in the control group (P < 0.05).Conclusion Probiotics is effective in the treatment of abdominal Henoch-Sch?nlein purpura in children, which can correct intestinal flora disorder, improve intestinal mucosal barrier function and immune response, and relieve clinical symptoms.