根性神经痛动物模型的研究进展

Research progress on animal models of radicular neuralgia

摘要:

根性神经痛是脊神经根由于各种原因受到伤害性刺激而引起的疼痛，其发病机制和预防治疗一直是国内外的研究热点。动物模型在阐明根性神经痛的发病机制、测试新药物和治疗方式的研究中起到了非常重要的作用。近年来，国内外研究者在根性神经痛的临床治疗和基础研究中取得了很大的进展，更多实用的根性神经痛动物模型被相继提出。该文通过对常见根性神经痛动物模型的种类及模型复制方法进行综述，以期为根性神经痛的动物实验研究提供参考。

Abstract:

adicular pain is the pain caused by the injurious stimulation of the spinal nerve root for various reasons, its pathogenesis and prophylaxis have always been a popular research topic in our country as well as abroad. Animal models play a very important role in elucidating the pathogenesis of radicular pain, testing new drugs and treatment methods. In recent years, domestic and foreign researchers have made great progress in the clinical treatment and basic research of radicular pain, and more practical animal models of radicular pain have been proposed successively. This article reviews the types and modeling methods of common animal models of radicular pain in order to provide reference for the animal experimental study of radicular pain.