Ⅱ度烧伤患者血清促红细胞生成素、细胞间黏附分子-1水平变化及与创面愈合程度的相关性分析

Serum levels of erythropoietin and intercellular adhesion molecule-1 in patients with second-degree burns and their relationship with the degree of wound healing

摘要:

目的 研究Ⅱ度烧伤患者血清促红细胞生成素（EPO）、细胞间黏附分子-1（ICAM-1）水平变化及与创面愈合程度的相关性。方法 选取2019年5月—2021年9月海南西部中心医院收治的89例Ⅱ度烧伤患者为研究对象。患者均接受重组牛碱性成纤维细胞生长因子凝胶、磺胺嘧啶锌软膏等治疗，治疗前检测患者血清EPO、ICAM-1水平，根据血清EPO、ICAM-1水平的中位数倍数（MOM）将患者分成高表达组（≥0.5 MOM）与低表达组（<0.5 MOM），治疗14 d后评估创面愈合程度。比较不同血清EPO、ICAM-1水平患者的创面愈合程度，Pearson分析血清EPO、ICAM-1水平与Ⅱ度烧伤患者创面愈合程度的相关性。结果 EPO高表达组患者创面愈合程度高于EPO低表达组（P <0.05），ICAM-1低表达组患者创面愈合程度高于ICAM-1高表达组（P <0.05）。Pearson相关性分析结果表明，血清EPO水平与Ⅱ度烧伤患者创面愈合程度呈正相关（r =0.475，P =0.000），血清ICAM-1水平与Ⅱ度烧伤患者创面愈合程度呈负相关（r =-0.529，P =0.000）。结论 Ⅱ度烧伤患者血清EPO水平与创面愈合程度呈正相关，血清ICAM-1水平与创面愈合程度呈负相关。

Abstract:

Objective To study the changes in the serum levels of erythropoietin (EPO) and intercellular adhesion molecule-1 (ICAM-1) in patients with second-degree burns and their relationship with the degree of wound healing.Methods A total of 89 patients with second-degree burns admitted to the hospital from May 2019 to September 2021 were selected. All patients received treatments including recombinant bovine basic fibroblast growth factor gel and sulfadiazine zinc. Serum levels of EPO and ICAM-1 in patients were detected before the treatments. According to the multiple of the median (MOM) of serum levels of EPO and ICAM-1, patients were divided into high expression (≥ 0.5 MOM) and low expression (< 0.5 MOM) groups. The degree of wound healing was evaluated after 14 days of treatments in the patients. The degrees of wound healing in patients with different serum levels of EPO and ICAM-1 were compared. Pearson method was used to analyze the correlation between serum levels of EPO and ICAM-1 and the degree of wound healing in patients with second-degree burns.Results The degree of wound healing in patients with high EPO expression was better than that in patients with low EPO expression (P < 0.05), and the degree of wound healing in patients with low ICAM-1 expression was better than that in patients with high ICAM-1 expression (P < 0.05). The Pearson correlation analysis showed that the serum level of EPO was positively correlated with the degree of wound healing in patients with second-degree burns (r = 0.475, P < 0.05), and the serum level of ICAM-1 was negatively correlated with the degree of wound healing in patients with second-degree burns (r = -0.529, P < 0.05).Conclusions The serum level of EPO is positively correlated with the degree of wound healing in patients with second-degree burns, while the serum level of ICAM-1 is negatively correlated with the degree of wound healing in these patients.