温阳宣肺方对哮喘急性发作期患者CXC型趋化因子的影响

Effect of Wenyang Xuanfei recipe on CXC chemokine in patients with acute exacerbation of asthma

摘要:

目的 探讨温阳宣肺方对哮喘急性发作期患者CXC型趋化因子的影响。方法 前瞻性选取2019年1月—2020年10月西南医科大学附属中医医院收治的126例哮喘急性发作期患者，根据奇偶数分组法分为两组。对照组给予西药对症治疗；观察组在西药基础上联合温阳宣肺方治疗。比较两组治疗后的临床效果。结果 观察组总有效率高于对照组（P <0.05）。两组治疗前后CXC型趋化因子12（CXCL12）、CXC型趋化因子13（CXCL13）、T辅助细胞1（Th1）、T辅助细胞2（Th2）及Th1/Th2的差值比较，差异有统计学意义（P <0.05），观察组优于对照组。两组治疗前后第1秒用力呼气容积占预计值百分比（FEV₁%）、第1秒用力呼气容积与用力肺活量比值（FEV₁/FVC）及呼气流量峰值（PEF）的差值比较，差异有统计学意义（P <0.05），观察组高于对照组。两组治疗前后喘息、咳嗽、气短、恶寒发热、头疼身痛、渴喜热饮等积分的差值比较，差异有统计学意义（P <0.05），观察组高于对照组。两组在用药期间不良反应比较，差异无统计学意义（P >0.05）。结论 温阳宣肺方治疗哮喘急性发作期患者可降低CXC型趋化因子的表达，调节Th1/Th2的失衡情况，改善患者肺功能。

Abstract:

Objective To observe the effect of Wenyang Xuanfei Recipe on CXC chemokine in patients with acute attack of asthma.Methods A total of 126 patients with acute asthma exacerbation in our hospital were prospectively selected and divided into two groups according to the odd-even grouping method. The control group was treated with symptomatic western medicine, the observation group was treated with Wenyang Xuanfei prescription on the basis of western medicine, and the clinical effects of the two groups were compared after treatment.Results The total effective rate in the observation group was higher than that in the control group, with statistical significance (P < 0.05). The ratio of CXCL12, CXCL13, Th1, Th2 cells, and the difference between Th1/Th2 before and after treatment in the two groups were compared by T test, and the differences were statistically significant (P < 0.05). The difference of Th1/Th2 and Th1/Th2 were higher than those of the control group. The differences of FEV₁%, FEV₁/FVC, and PEF between the two groups before and after treatment were compared, and the T test showed that the differences were statistically significant (P < 0.05). The differences of FEV₁%, FEV₁/FVC, and PEF in the observation group were higher than those in the control group. Differences in the scores of wheezing, cough, shortness of breath, aversion to cold and fever, headache and body pain, and thirst for hot drinks before and after treatment in the two groups were compared, and the difference was statistically significant by T test (P < 0.05). Shortness of breath, aversion to cold and fever, headache and body pain, and thirst for hot drink scores were higher than those in the control group. There was no statistical significance in the comparison of adverse reactions between the two groups during the treatment period (P > 0.05).Conclusion Wenyang Xuanfei decoction can reduce the expression of CXC chemokine, regulate the imbalance of Th1 / Th2 cells, and improve lung function.