MicroRNA在腹膜透析中的研究进展

Research progress of microRNA in peritoneal dialysis

摘要:

腹膜透析是终末期肾病患者的主要治疗方式之一，因有能更好地保护残余肾功能等优势，具有广泛的应用前景。但长期腹膜透析容易出现多种并发症，其中腹膜透析相关性腹膜炎是最常见的并发症之一，反复发生的炎症刺激会加速腹膜纤维化的发展，最终导致超滤衰竭，腹膜透析失败。MicroRNA（miRNA）属于非编码RNA的一种，在炎症及纤维化过程中的作用备受关注，众多miRNA参与了腹膜炎症及纤维化过程。新近研究显示，腹膜透析过程中，多种miRNA的表达谱发生了改变。该文就miRNA在腹膜透析中的研究进展进行综述。

Abstract:

Peritoneal dialysis (PD) is one of the main treatment methods for patients with end-stage renal disease. It has a wide application prospect due to its advantages of better protection of residual renal function. However, long-term PD is prone to multiple complications, of which peritoneal dialysis-related peritonitis is one of the most common complications. Repeated inflammatory stimuli will accelerate the development of peritoneal fibrosis and eventually lead to ultrafiltration failure and peritoneal dialysis disfunction. MicroRNA (miRNA) are one of the non-coding RNA, and their role in inflammation and fibrosis has attracted much attention. Studies have shown that numerous miRNA are involved in peritoneal inflammation and fibrosis. Recent studies have shown that the expression profile of a variety of miRNA changes during peritoneal dialysis. This article reviews the research progress of miRNAs in peritoneal dialysis.