病毒性脑炎相关细胞因子和趋化因子的变化特点及作用机制

Changes and roles of cytokines and chemokines in viral encephalitis

摘要:

病毒感染及免疫诱导的炎症损伤在病毒性脑炎（VE）的发生、发展及预后方面发挥重要作用。细胞因子白细胞介素2、白细胞介素6、肿瘤坏死因子-α、B细胞激活因子和增殖诱导配体，细胞趋化因子CXCL8、CXCL9、CXCL10、CXCL11、CXCL13、CCL19等与VE的免疫过程密切相关，因此研究VE相关细胞因子和趋化因子对探究疾病的发病机制、治疗及预后预测具有重要指导意义。

Abstract:

The injury due to inflammation induced by viral infection and related immune responses plays an important role in the occurrence, development and prognosis of viral encephalitis (VE). Cytokines such as interleukin (IL)-2, IL-6, tumor necrosis factor-α, B-cell activating factor, and a proliferation-inducing ligand, and chemokines including CXCL8, CXCL9, CXCL10, CXCL11, CXCL13, and CCL19, are closely associated with the immunopathogenesis of VE. Therefore, the exploration of cytokines and chemokines related to VE is of guiding significance for understanding the pathogenesis, treatment and prognosis of the disease.