Abstract:Objective To explore the effect of multimodal exercise intervention on lower extremity motor function and fatigue in patients with stroke.Methods A total of 98 stroke patients from March 2020 to March 2022 in the first affiliated hospital of Soochow University were randomly divided into control group (n = 49) and study group (n = 49). The control group was treated with routine rehabilitation therapy, and the research group was treated with multimodal exercise intervention on the basis of routine rehabilitation therapy. The cognitive function, limb function, ability of daily living, psychological status and self-efficacy, gait parameters, and fatigue degree were compared between the two groups.Results After intervention, the scores of MMSE, FMA, BI, GSES, pace, stride length, and stride frequency of the two groups were higher than those before intervention, and the scores of S-AI, T-AI, mental fatigue, activity decrease, physical fatigue, activity decrease, and overall fatigue were all lower than those before intervention (P < 0.05). After intervention, the scores of MMSE, FMA, BI, GSES, pace, stride length, and stride frequency of the research group were higher than those of the control group, and the scores of S-AI, T-AI, mental fatigue, activity decrease, physical fatigue, activity decrease, and overall fatigue were all lower than those of the control group (P < 0.05).Conclusion The effect of multimodal exercise intervention on stroke patients is obvious. It can not only relieve the bad mood and fatigue state, improve self-efficacy, but also improve the motor function of lower limbs, walking ability, and daily life ability.