Akk菌在消化道疾病中的研究进展

Advances in the roles of Akkermansia muciniphila in gastrointestinal diseases

摘要:

Akk菌及其衍生物作为下一代益生菌中的明星菌株，已被证实与炎症性肠病（IBD）、结直肠癌（CRC）、肝病等消化道疾病具有相关性，且其在上述疾病中的积极作用及具体机制也逐渐被揭晓。该文在最新试验的基础上，从Akk菌株及其主要衍生物的生化特征，Akk菌在IBD、CRC、肝病中的保护性作用及机制等方面入手，对这些疾病的临床诊断和治疗做出了展望。

Abstract:

As a star strain of next-generation probiotics, Akkermansia muciniphila (Akk) and its derivatives have been shown to be associated with inflammatory bowel disease (IBD), colorectal cancer (CRC), liver disease and other digestive disorders, and its positive roles and specific mechanisms in these diseases have been gradually uncovered. This review, based on the latest trials, provides a prospect for applying Akk in the clinical diagnosis and treatment of aforementioned diseases, from the perspectives of the biochemical characteristics of Akk strains and their main derivatives, and their protective roles and underlying mechanisms.