肠道菌群与microRNA失调对慢传输型便秘的影响

Effects of intestinal flora and microRNA dysregulation on slow transit constipation

摘要:

慢传输型便秘是一种常见的临床疾病，患者常伴有肠道菌群的改变。肠道菌群对维持人体健康有重要作用，若肠道菌群的结构和功能发生变化，出现肠道菌群紊乱，则可能引起便秘等疾病。MicroRNA是一种小的非编码RNA，作为基因表达过程转录后调控因子，其具有调节包括胃肠道在内的所有细胞蛋白表达的作用。肠道菌群能通过microRNA调节宿主基因的表达，而宿主的microRNA同样能调节菌群的生长和基因表达。肠道菌群与microRNA在维持肠道内稳态和预防相关疾病方面发挥着重要作用。该文就肠道菌群与宿主microRNA对慢传输型便秘影响的研究进展进行综述。

Abstract:

Slow transit constipation is a common clinical disease, and its patients are often accompanied by changes in intestinal flora. The intestinal flora plays an important role in maintaining human health. If the structure and function of the intestinal flora changes, and the intestinal flora is disturbed, it may cause diseases such as constipation. MicroRNA is small non-coding RNA that act as post-transcriptional regulators of gene expression levels and regulate protein expression in all cells, including the gastrointestinal tract. The regulation of microRNA at the gene level affects almost all biological processes in the body. Studies have shown that intestinal flora can regulate the expression of host genes through microRNA, and the host microRNA can also regulate the growth and gene expression of bacterial flora. Intestinal flora and microRNAs play an important role in maintaining intestinal homeostasis and preventing related diseases. This article reviews the research progress of the effects of intestinal microbiota and host microRNA on slow transit constipation.