TET2基因单核苷酸多态性与急性心肌梗死易感性的关系

Association between single nucleotide polymorphism of TET2 gene and susceptibility to acute myocardial infarction

摘要:

目的 探讨TET2基因单核苷酸多态性（rs2454206、rs12498609）与急性心肌梗死易感性的相关性。方法 前瞻性选取2022年1月—2022年9月承德医学院附属医院收治的急性心肌梗死患者作为病例组，另选取同期该院健康人群作为对照组，每组150例。比较两组一般资料及血脂相关指标，采用实时荧光定量聚合酶链反应（qRT-PCR）检测TET2基因rs2454206、rs12498609位点基因型，采用多因素Logistic逐步回归分析影响急性心肌梗死发生的危险因素。结果 两组TET2基因rs2454206位点、rs12498609位点基因型频率、等位基因频率比较，差异均有统计学意义（P <0.05）。多因素Logistic逐步回归分析显示，高血压［O^R=2.022（95% CI：1.202，3.401）］、TC［O^R=3.045（95% CI：2.146，4.320）］、TG［O^R=4.052（95% CI：2.405，6.826）］、LDL-C［O^R=3.022（95% CI：1.889，4.834）］、rs2454206位点AA基因型［O^R=4.697（95% CI：2.675，8.249）］、rs12498609位点CC基因型［O^R=2.147（95% CI：1.215，3.795）］是影响急性心肌梗死发生的危险因素（P <0.05），HDL-C［O^R=0.057（95% CI：0.015，0.216）］是影响急性心肌梗死发生的保护因素（P <0.05）。结论 急性心肌梗死的发生受多种因素影响，其中TET2基因rs2454206位点AA基因型、rs12498609位点CC基因型可能与急性心肌梗死易感性增加有关。

Abstract:

Objective To investigate the relationship between single nucleotide polymorphism of TET2 gene (rs2454206, rs12498609) and susceptibility to acute myocardial infarction.Methods We prospectively selected 150 patients with acute myocardial infarction admitted to our hospital as the case group from January 2022 to December 2022, and 150 healthy people admitted for physical examination in the same period as the control group. We compared the general data and blood lipid related indicators between the two groups, and determined the genotypes of rs2454206 and rs12498609 of TET2 gene by polymerase chain reaction (PCR). Logistic regression analysis was used to analyze the risk factors of acute myocardial infarction.Results There were significant differences in genotype frequency and allele frequency at rs2454206 and rs12498609 of TET2 gene between the two groups (P < 0.05). The results of univariate and multivariate logistic regression showed that Hypertension [O^R = 2.022 (95% CI: 1.202, 3.401) ], TC [O^R = 3.045 (95% CI: 2.146, 4.320) ], TG [O^R = 4.052 (95% CI: 2.405, 6.826) ], LDL-C [O^R = 3.022 (95% CI: 1.889, 4.834) ] level, TET2 gene rs2454206 locus AA genotype [O^R = 4.697 (95% CI: 2.675, 8.249) ], rs12498609 locus CC genotype [O^R = 2.147 (95% CI: 1.215, 3.795) ] were risk factors affecting the occurrence of acute myocardial infarction (P < 0.05), HDL-C level [O^R = 0.057 (95% CI: 0.015, 0.216) ] was a protective factor affecting the occurrence of acute myocardial infarction (P < 0.05).Conclusion The occurrence of acute myocardial infarction is affected by many factors. The AA genotype at rs2454206 and CC genotype at rs12498609 of TET2 gene may be related to the increased susceptibility to acute myocardial infarction.