首页 > 过刊浏览>2023年第卷第13期 >72-77. DOI:10.3969/j.issn.1005-8982.2023.13.012
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应激诱导炎症反应与下尿路症状的研究进展
作者:
作者单位:

中南大学湘雅三医院 肾内与风湿免疫科， 湖南 长沙 410083

通讯作者:

刘纪实，E-mail：26545559@qq.com；Tel：13317311123

中图分类号:

R691

基金项目:

国家自然科学基金（No：82070738，82270750）；湖南省自然科学基金（No：2021JJ31015）；湖南省卫生健康委基金（No：202103050563，202104022248）；2021年度湖南省临床医疗技术创新引导项目（No：2021SK53708）；中南大学大型仪器设备共享基金项目（No：CSUZC202250）


Research progress on stress-induced inflammatory response and lower urinary tract symptoms
Author:
Affiliation:

Department of Nephrology and Rheumatology, the Third Xiangya Hospital of Central South University, Changsha, Hunan 410083, China

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    摘要:

    下尿路症状（LUTS）是一组包括储存、排尿及排尿后不适的非特异性泌尿系统症状，发病率较高，且病因和发病机制较复杂。应激作为导致LUTS的独立危险因素，通过诱导全身炎症反应在局部膀胱和排尿中枢中发挥作用，参与LUTS的发生发展。该文围绕应激诱导炎症反应与LUTS的发病机制展开综述。

    参考文献
    [1] ABRAMS P, BLAIVAS J G, STANTON S L, et al. The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the international continence society-urology[J]. Eur Urol, 1977, 3(3):168-170.
    [2] 张蕾. 中国成年女性下尿路症状流行病学调查及随访研究——多中心横断面及前瞻性队列研究[D]. 北京: 北京协和医学院, 2015.
    [3] CHAPPLE C, CASTRO-DIAZ D, CHUANG Y C, et al. Prevalence of lower urinary tract symptoms in China and the republic of Korea: results from a cross-sectional, population-based study[J]. Adv Ther, 2017, 34(8): 1953-1965.
    [4] CALOGERO A E, BURGIO G, CONDORELLI R A, et al. Epidemiology and risk factors of lower urinary tract symptoms/benign prostatic hyperplasia and erectile dysfunction[J]. Aging Male, 2019, 22(1): 12-19.
    [5] LAI J Y, GE M Q, SHEN S K, et al. Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation[J]. Biochim Biophys Acta Mol Basis Dis, 2019, 1865(9): 2403-2410.
    [6] KIM I B, LEE J H, PARK S C. The relationship between stress, inflammation, and depression[J]. Biomedicines, 2022, 10(8): 1929.
    [7] CORTES E, SAHAI A, PONTARI M, et al. The psychology of LUTS: ICI-RS 2011[J]. Neurourol Urodyn, 2012, 31(3): 340-343.
    [8] ZHANG Q, PANG S Y, ZHANG Y L, et al. Association between inflammation and lower urinary tract symptoms of benign prostatic hyperplasia[J]. Urol J, 2020, 17(5): 505-511.
    [9] LU S Y, WEI F, LI G L. The evolution of the concept of stress and the framework of the stress system[J]. Cell Stress, 2021, 5(6): 76-85.
    [10] PETERLIK D, FLOR P J, USCHOLD-SCHMIDT N. The emerging role of metabotropic glutamate receptors in the pathophysiology of chronic stress-related disorders[J]. Curr Neuropharmacol, 2016, 14(5): 514-539.
    [11] CHESS-WILLIAMS R, MCDERMOTT C, SELLERS D J, et al. Chronic psychological stress and lower urinary tract symptoms[J]. Low Urin Tract Symptoms, 2021, 13(4): 414-424.
    [12] FUENTES I M, PIERCE A N, di SILVESTRO E R, et al. Differential influence of early life and adult stress on urogenital sensitivity and function in male mice[J]. Front Syst Neurosci, 2018, 11: 97.
    [13] MANN E A, ALAM Z, HUFGARD J R, et al. Chronic social defeat, but not restraint stress, alters bladder function in mice[J]. Physiol Behav, 2015, 150: 83-92.
    [14] PIERCE A N, DI SILVESTRO E R, ELLER O C, et al. Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress[J]. Brain Res, 2016, 1639: 58-73.
    [15] COYNE K S, WEIN A J, TUBARO A, et al. The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS[J]. BJU Int, 2009, 103 Suppl 3: 4-11.
    [16] LAI H H, RAWAL A, SHEN B X, et al. The relationship between anxiety and overactive bladder or urinary incontinence symptoms in the clinical population[J]. Urology, 2016, 98: 50-57.
    [17] FELDE G, EBBESEN M H, HUNSKAAR S. Anxiety and depression associated with urinary incontinence. A 10-year follow-up study from the Norwegian HUNT study (EPINCONT)[J]. Neurourol Urodyn, 2017, 36(2): 322-328.
    [18] HILL A R, SPENCER-SEGAL J L. Glucocorticoids and the brain after critical illness[J]. Endocrinology, 2021, 162(3): bqaa242.
    [19] LIBERMAN A C, TRIAS E, da SILVA CHAGAS L, et al. Neuroimmune and inflammatory signals in complex disorders of the central nervous system[J]. Neuroimmunomodulation, 2018, 25(5/6): 246-270.
    [20] GüLKE E, GELDERBLOM M, MAGNUS T. Danger signals in stroke and their role on microglia activation after ischemia[J]. Ther Adv Neurol Disord, 2018, 11: 1756286418774254.
    [21] BRINKMAN D J, TEN HOVE A S, VERVOORDELDONK M J, et al. Neuroimmune interactions in the gut and their significance for intestinal immunity[J]. Cells, 2019, 8(7): 670.
    [22] RHIE S J, JUNG E Y, SHIM I. The role of neuroinflammation on pathogenesis of affective disorders[J]. J Exerc Rehabil, 2020, 16(1): 2-9.
    [23] MARSLAND A L, WALSH C, LOCKWOOD K, et al. The effects of acute psychological stress on circulating and stimulated inflammatory markers: a systematic review and meta-analysis[J]. Brain Behav Immun, 2017, 64: 208-219.
    [24] ROHLEDER N. Stimulation of systemic low-grade inflammation by psychosocial stress[J]. Psychosom Med, 2014, 76(3): 181-189.
    [25] BIERHAUS A, WOLF J, ANDRASSY M, et al. A mechanism converting psychosocial stress into mononuclear cell activation[J]. Proc Natl Acad Sci U S A, 2003, 100(4): 1920-1925.
    [26] KUEBLER U, ZUCCARELLA-HACKL C, ARPAGAUS A, et al. Stress-induced modulation of NF-κB activation, inflammation-associated gene expression, and cytokine levels in blood of healthy men[J]. Brain Behav Immun, 2015, 46: 87-95.
    [27] SILVERMAN M N, STERNBERG E M. Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction[J]. Ann N Y Acad Sci, 2012, 1261: 55-63.
    [28] KIECOLT-GLASER J K, PREACHER K J, MACCALLUM R C, et al. Chronic stress and age-related increases in the proinflammatory cytokine IL-6[J]. Proc Natl Acad Sci U S A, 2003, 100(15): 9090-9095.
    [29] HINTIKKA J, LEHTO S M, NISKANEN L, et al. Unemployment and ill health: a connection through inflammation?[J]. BMC Public Health, 2009, 9: 410.
    [30] H?FNER S, EMENY R T, LACRUZ M E, et al. Association between social isolation and inflammatory markers in depressed and non-depressed individuals: results from the MONICA/KORA study[J]. Brain Behav Immun, 2011, 25(8): 1701-1707.
    [31] BLACK P H. Stress and the inflammatory response: a review of neurogenic inflammation[J]. Brain Behav Immun, 2002, 16(6): 622-653.
    [32] COUZIN-FRANKEL J. Inflammation bares a dark side[J]. Science, 2010, 330(6011): 1621.
    [33] HE Q, WANG Z, LIU G, et al. Metabolic syndrome, inflammation and lower urinary tract symptoms: possible translational links[J]. Prostate Cancer Prostatic Dis, 2016, 19(1): 7-13.
    [34] FREEDLAND S J, ARONSON W J. Invited commentary: lower urinary tract symptoms and inflammation--weighing the evidence[J]. Am J Epidemiol, 2009, 169(11): 1291-1293.
    [35] MARTIN S, VINCENT A, TAYLOR A W, et al. Lower urinary tract symptoms, depression, anxiety and systemic inflammatory factors in men: a population-based cohort study[J]. PLoS One, 2015, 10(10): e0137903.
    [36] XIA B W, ZHAO S C, CHEN Z P, et al. The underlying mechanism of metabolic syndrome on benign prostatic hyperplasia and prostate volume[J]. Prostate, 2020, 80(6): 481-490.
    [37] THEOHARIDES T C, ALYSANDRATOS K D, ANGELIDOU A, et al. Mast cells and inflammation[J]. Biochim Biophys Acta, 2012, 1822(1): 21-33.
    [38] UY J, YU M, JIANG X W, et al. Glutamatergic mechanisms involved in bladder overactivity and pudendal neuromodulation in cats[J]. J Pharmacol Exp Ther, 2017, 362(1): 53-58.
    [39] MAIER S F, WATKINS L R. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition[J]. Psychol Rev, 1998, 105(1): 83-107.
    [40] MCKAY L I, CIDLOWSKI J A. Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways[J]. Endocr Rev, 1999, 20(4): 435-459.
    [41] KESSLER W, TRAEGER T, WESTERHOLT A, et al. The vagal nerve as a link between the nervous and immune system in the instance of polymicrobial sepsis[J]. Langenbecks Arch Surg, 2006, 391(2): 83-87.
    [42] HOFER S, EISENBACH C, LUKIC I, et al. Pharmacologic inhibition of cholinesterase improves survival in experimental sepsis[J]. Crit Care, 2007, 11(Suppl 2): P25.
    [43] van GOOL J, van VUGT H, HELLE M, et al. The relation among stress, adrenalin, interleukin 6 and acute phase proteins in the rat[J]. Clin Immunol Immunopathol, 1990, 57(2): 200-210.
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潘诗琪,李怡素,李楠楠,刘纪实.应激诱导炎症反应与下尿路症状的研究进展[J].中国现代医学杂志,2023,(13):72-77

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  • 收稿日期:2023-02-25
  • 在线发布日期: 2023-12-04
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