R-spondins与乳腺癌的相关性研究进展

Progress on correlation between R-spondins and breast cancer

摘要:

乳腺癌是我国女性最常见的恶性肿瘤，对女性的身心健康构成严重的威胁。随着分子及基因水平研究的不断深入，越来越多的在恶性肿瘤发生发展中发挥重要功能的基因相继被发现。R-spondins也称为特异性顶部盘状底板反应蛋白（RSPO），属于一种新型的分泌蛋白质家族，在维持机体生长发育等方面发挥重要的生理功能。RSPO蛋白成员在包括乳腺癌等多个实体肿瘤中表达失调，并与乳腺癌的发生发展密切相关。该文就RSPO在乳腺癌中的研究现状作一综述，为精准治疗乳腺癌提供参考依据。

Abstract:

Breast cancer is the most common malignant tumor in Chinese women, and has posed a serious threat to the physical and mental health of women. With the development of the molecular and gene technology, a growing number of genes have been discovered that play important roles in the occurrence and development of malignant tumors. R-spondins, also known as roof plate specific spondin (RSPOs), are a new family of secreted proteins that play important physiological functions in maintaining body growth and development. Recent studies shown that its members are dysregulated in several solid tumors and are closely related to the occurrence and development of breast cancer. This paper reviews the progress of the function and related mechanisms of the RSPOs in breast cancer, which may provide some reference for its precise treatment.