骨质疏松相关长链非编码RNA的研究进展

Research progress of long non-coding RNAs associated with osteoporosis

摘要:

骨质疏松是一种较为常见的全身性骨骼代谢疾病，受环境和基因的共同影响，以骨量减少及骨小梁微结构改变为特征，导致骨脆性增加和骨折风险增高，给患者的生活质量产生严重的负面影响。随着骨质疏松病因研究的深入，越来越多的证据表明，表观遗传修饰可能是遗传和环境因素与骨质疏松之间联系的机制。长链非编码RNA（LncRNA）是一种重要的表观遗传调节因子，在基因表达调控中发挥着重要的作用，影响着包括骨代谢在内的多种生物学过程。该文综述LncRNA介导的与骨髓间充质干细胞、成骨细胞和破骨细胞相关的骨质疏松机制的最新研究结果，深入了解LncRNA在骨质疏松中的作用，为骨质疏松的诊断及治疗提供理论依据。

Abstract:

Osteoporosis is a common systemic bone metabolic disease. Influenced by both the environment and genes, it is characterized by reduced bone mass and changes in the microstructure of bone trabeculae, resulting in increased bone fragility and increased risk of fracture, which has a serious negative impact on patients' quality of life. With the further research on the etiology of osteoporosis, more and more evidences suggest that epigenetic modification may be the mechanism of the link between genetic and environmental factors and osteoporosis. Long non-coding RNA (LncRNA) is an important epigenetic regulator, which plays an important role in the regulation of gene expression and affects a variety of biological processes including bone metabolism. This paper reviewes the latest research results of LncRNA-mediated osteoporosis mechanism related to bone mesenchymal stem cells, osteoblasts and osteoclasts, and the role of LncRNA in osteoporosis is deeply understood, providing theoretical basis for the diagnosis and treatment of osteoporosis.