锌指样转录因子4在肺动脉高压中的研究进展

Research progress of zinc finger-like transcription factor 4 in pulmonary hypertension

摘要:

锌指样转录因子4（KLF4）是一种结构上保守的含锌指转录因子，可调控细胞生长、增殖及分化。KLF4是一种炎症反应调节因子，在血管重塑中发挥重要作用。KLF4通过调控平滑肌细胞表型转换、内皮功能障碍、炎症浸润等参与肺血管重塑。KLF4在血管重塑中的具体机制目前尚不明确，该文就KLF4在血管重塑中的作用展开综述。

Abstract:

Krüppel-like factor 4（KLF4）is a structurally conserved zinc-containing finger transcription factor that regulates cell growth, proliferation, and differentiation. KLF4 is a regulator of inflammation and plays an important role in vascular remodeling. KLF4 participates in pulmonary vascular remodeling by regulating smooth muscle cell phenotypic conversion, endothelial dysfunction, and inflammatory infiltration. The specific mechanism of KLF4 in vascular remodeling is not clear, this article reviews the role of KLF4 in vascular remodeling.