杞菊地黄丸联合玻璃酸钠滴眼液治疗干眼症的效果分析

Efficacy of Qiju Dihuang Pill combined with sodium hyaluronate eye drops in the treatment of xerophthalmia

摘要:

目的 探讨杞菊地黄丸联合玻璃酸钠滴眼液治疗干眼症的疗效。方法 选取2020年4月—2022年4月南通市中医院眼科收治的干眼症患者104例。将患者以随机数字表法分为研究组和对照组，每组52例。对照组予以玻璃酸钠滴眼液治疗，研究组则在对照组的基础上增用杞菊地黄丸。对比两组患者临床疗效，治疗前后泪液分泌试验（SIT）以及泪膜破裂时间（BUT）水平，治疗前后泪液中溶菌酶、表皮生长因子（EGF）以及乳铁蛋白（LF）水平。结果 研究组总有效率高于对照组（P <0.05）。两组患者治疗前SIT、BUT比较，差异无统计学意义（P >0.05）。研究组治疗后SIT、BUT高于对照组（P <0.05）。研究组治疗前后SIT、BUT的差值高于对照组（P <0.05）。两组患者治疗前泪液中溶菌酶、EGF、LF比较，差异无统计学意义（P >0.05）。研究组治疗后泪液中溶菌酶、EGF、LF高于对照组（P <0.05）。研究组治疗前后泪液中溶菌酶、EGF、LF的差值高于对照组（P <0.05）。结论 杞菊地黄丸联合玻璃酸钠滴眼液治疗干眼症的临床效果较佳，可显著改善基础泪液分泌。

Abstract:

Objective To study the clinical effect of Qiju Dihuang Pill combined with sodium hyaluronate eye drops in the treatment of xerophthalmia.Methods A total of 104 xerophthalmia patients admitted to the Department of Ophthalmology of Nantong Hospital of Traditional Chinese Medicine were selected and divided into study group and control group by the random number table method, with 52 cases in each group. The control group was treated with sodium hyaluronate eye drops, while the study group was additionally given Qiju Dihuang Pill. The clinical effects of the two groups were compared. The positive rate of Schirmer I test (SIT), tear breakup time (BUT), and the levels of lysozyme, epidermal growth factor (EGF) and lactoferrin (LF) in tears before and after the treatment were also compared between the two groups.Results The overall effective rate of the study group was higher than that of the control group (P < 0.05). There was no significant difference in the positive rate of SIT and BUT between the two groups before the treatment (P > 0.05), while the positive rate of SIT and BUT after the treatment in the study group were higher than those in the control group (P < 0.05). The differences of the positive rate of SIT and BUT before and after the treatment in the study group were higher than those in the control group (P < 0.05). There was no significant difference in the levels of lysozyme, EGF and LF in tears between the two groups before the treatment (P > 0.05). After the treatment, the levels of lysozyme, EGF and LF in tears of the study group were higher than those of the control group (P < 0.05), and the differences of the levels of lysozyme, EGF and LF in tears before and after the treatment in the study group were higher than those in the control group (P < 0.05).Conclusions Qiju Dihuang Pill combined with sodium hyaluronate eye drops shows great efficacy in the treatment of xerophthalmia by significantly improving basic tear secretion.