Notch信号通路在肾脏疾病中作用机制的研究进展

Research progress on mechanism of Notch signaling pathway in kidney disease

摘要:

Notch是一条进化保守的信号通路，在细胞的生长、分化、迁移及程序性死亡等过程中具有关键作用。随着研究的深入，越来越多证据表明Notch信号通路是肾脏发育、损伤或修复的关键调节因子。该文从炎症反应、调控细胞死亡、肾脏纤维化、调控足细胞损伤、血管相关性病变等5个方面阐述Notch信号通路对肾脏的作用，并总结了干预Notch通路的多个靶点及相关药物，为提高肾脏疾病防治水平提供新的思路或策略。

Abstract:

Notch is an evolutionarily conserved signaling pathway with key roles in cell growth, differentiation, migration, and programmed death. As research progresses, there is increasing evidence that the Notch signaling pathway is a key regulator of kidney development, injury, or repair. In this paper, we describe the key effects of Notch signaling pathway on kidney disease from five aspects, including involvement in inflammatory response, regulation of fibrosis, regulation of cell death, regulation of podocyte injury, and involvement in vascular-associated lesions, and summarize multiple targets and related drugs that interfere with Notch pathway to provide new ideas or strategies to improve the prevention and treatment of kidney disease.