线粒体自噬相关调控通路在慢性阻塞性肺疾病发病机制中的作用研究进展

Research progress on the role of mitochondrial autophagy related regulatory pathways in the pathogenesis of chronic obstructive pulmonary disease

摘要:

线粒体自噬是一种选择性自噬，通过清除受损线粒体来维持细胞及代谢的稳态。慢性阻塞性肺疾病（COPD）是一种以持续存在的呼吸系统症状和气流受限为特征的常见慢性疾病，其发病机制复杂，至今仍未完全明确。许多研究表明调控线粒体自噬的多条信号通路在COPD进展中发挥重要作用。本文阐述了PINK1/Parkin、FUNDC1和Nix等相关通路通过调控线粒体自噬在COPD中作用的研究现状，并总结了近几年取得的重要研究进展，为进一步研究线粒体自噬在COPD相关通路中的调控作用提供合理的理论基础。

Abstract:

Mitophagy is a kind of selective autophagy that maintains cellular and metabolic homeostasis by removing damaged mitochondria. Chronic obstructive pulmonary disease (COPD) is a kind of persistent respiratory symptoms and limited airflow of common chronic disease, characterized by its pathogenesis is complex, is still not completely clear.Many studies have shown that multiple signaling pathways regulating mitophagy play an important role in the progression of COPD. This article describes the research status of PINK1/Parkin, FUNDC1, Nix and other related pathways in the regulation of mitophagy in COPD, and summarizes the important research progress in recent years, so as to provide a reasonable theoretical basis for further research on the regulation of mitophagy in COPD related pathways.