遗传易感、内质网应激及肠道微生物在非酒精性脂肪性肝炎发病中的作用

The roles of genetic susceptibility, endoplasmic reticulum stress, and gut microbiota in the pathogenesis of nonalcoholic steatohepatitis

摘要:

非酒精性脂肪性肝炎（NASH）是最常见的慢性肝脏疾病，随着2型糖尿病、肥胖症和代谢综合征等疾病的增加，NASH的发病率不断升高，其发病机制复杂且尚未完全阐明。目前，遗传易感、内质网应激和肠道微生物与NASH发病机制的相关性是研究热点，故该文从以上三方面回顾了NASH的最新发病机制研究，希望能为NASH发病机制和新靶点药物的研究提供参考。

Abstract:

Non-alcoholic steatohepatitis (NASH) is the most common chronic hepatopathy. With the increase in the prevalence of type 2 diabetes, obesity, and metabolic syndrome among other diseases, the incidence of NASH continues to rise. The pathogenesis of NASH is complex and has not been fully elucidated. Currently, the relevance of genetic susceptibility, endoplasmic reticulum stress and gut microbiota with the pathogenesis of NASH represents a hot topic in the research field. Thus, this review summarizes the latest studies on the pathogenesis of NASH from these three aspects, aiming to provide a reference for studies on the pathogenesis and novel drug targets of NASH.