Th17/Treg细胞免疫平衡的相关调控机制研究进展

Research advances in the regulatory mechanism of immune balance between Th17 and Treg cells

摘要:

免疫系统可识别、抵抗病原微生物及清除体内异常分裂的细胞，平衡的免疫系统对维持正常的机体反应活动至关重要。人体内的多种细胞都可参与维持免疫稳态，其中辅助性T淋巴细胞17（Th17）和调节性T淋巴细胞（Treg）发挥着重要作用，失衡的免疫系统可致多种免疫性疾病的发生。Th17/Treg细胞平衡受细胞因子、代谢、肠道微生态及翻译后修饰等多种机制调控，该文通过总结相关机制为免疫性疾病治疗提供新思路和策略。

Abstract:

The immune system recognizes and fights off pathogenic microorganisms and clears abnormally dividing cells in the body, and its balance is critical to maintaining normal responses and activities of the body. A variety of cells in the human body participate in the maintenance of immune homeostasis, among which T helper 17 (Th17) cells and regulatory T (Treg) cells play an essential role. The unbalanced immune system could lead to the occurrence of multiple immune diseases. The Th17/Treg cell balance is regulated in various ways involving cytokines, metabolism, intestinal microbiome, and post-translational modification. This review may provide novel insights and strategies for the treatment of immune diseases by summarizing the relevant mechanisms.