利钠肽受体家族在恶性肿瘤发生、发展中的作用及临床应用价值

The role and clinical application of Natriuretic Peptide Receptor family in the development of malignant tumors

摘要:

利钠肽受体（NPR）家族包括利钠肽受体A（NPRA）、利钠肽受体B（NPRB）及利钠肽受体C（NPRC）。除NPRC、NPRA和NPRB属于鸟苷酸环化酶受体家族的成员。NPR家族广泛分布于人体中，具有多种生理功能。NPR家族在许多恶性肿瘤中表达，在肿瘤的发生发展中起着重要调控作用。NPR家族在恶性肿瘤中的表达和功能已在许多动物模型和研究中得到证实，但NPR家族表达的机制尚不清楚，对其机制的研究尚未应用于肿瘤的临床治疗。该文综述了NPR家族在恶性肿瘤发生、发展中的作用及其潜在的临床价值。

Abstract:

The natriuretic peptide receptor (NPR) family consists of natriuretic peptide receptor A (NPRA), natriuretic peptide receptor B (NPRB), and natriuretic peptide receptor C (NPRC). Except for NPRC, both NPRA and NPRB belong to the guanylate cyclase receptor family. The NPR family is widely distributed in the human body and possesses various physiological functions. The NPR family is expressed in numerous malignant tumors, where it plays a crucial regulatory role in the initiation and progression of these cancers. The expression and function of the NPR family in malignant tumors have been confirmed in many animal models and studies. However, the mechanisms underlying NPR family expression remain unclear, and research on these mechanisms has not yet been applied to clinical cancer therapy. This article reviews the roles of the NPR family in the occurrence and development of malignant tumors and discusses their potential clinical value.