幽门螺杆菌抗生素耐药影响因素的研究进展

Research progress on factors influencing antibiotic resistance of helicobacter pylori

摘要:

幽门螺杆菌是一种全球流行率较高的人类病原体，与胃肠道内外多种疾病有关，根除幽门螺杆菌对防治这些疾病至关重要。抗生素治疗仍然是目前根除幽门螺杆菌的主要手段，然而，幽门螺杆菌抗生素耐药性的出现使其根除成功率明显下降。除了用药敏试验和耐药基因的检测指导抗生素的有效使用，分析与抗生素耐药发病率增加相关的临床影响因素对临床医生经验性为患者选择合适的抗生素治疗同样意义重大。该文就与幽门螺杆菌抗生素耐药相关临床影响因素的研究现状和进展作一综述。

Abstract:

Helicobacter pylori is a human pathogen with high global prevalence and is associated with a variety of diseases in and outside the gastrointestinal tract, and eradication of Helicobacter pylori is essential to prevent and treat these diseases. Antibiotic therapy remains the primary means of Helicobacter pylori eradication at present; however, the emergence of antibiotic resistance to Helicobacter pylori has significantly reduced its eradication success. In addition to drug sensitivity testing and detection of resistance genes to guide the effective use of antibiotics, analysis of clinical influencing factors associated with the increased incidence of antibiotic resistance is also significant for clinicians to empirically select the appropriate antibiotic therapy for each patient.