血清IGFBP-3、PDGF及bFGF联合检测对多囊卵巢综合征患者妊娠结局的预测价值

The predictive value of combined detection of serum IGFBP-3, PDGF and bFGF on pregnancy outcome in patients withpolycystic ovary syndrome

摘要:

目的 探究血清胰岛素样生长因子结合蛋白-3（IGFBP-3）、血小板来源生长因子（PDGF）及碱性成纤维细胞生长因子（bFGF）联合检测对多囊卵巢综合征（PCOS）患者妊娠结局的预测价值。方法 选取2021年5月—2022年12月在沧州市中心医院接受治疗的150例PCOS孕妇作为PCOS组，另选取同期在该院产检健康的90例孕妇作为对照组。比较两组血清IGFBP-3、PDGF及bFGF水平；根据PCOS组孕妇的妊娠情况分为妊娠结局良好组119例和妊娠结局不良组31例，统计PCOS患者妊娠结局情况并比较血清IGFBP-3、PDGF、bFGF水平；绘制受试者工作特征（ROC）曲线分析血清IGFBP-3、PDGF和bFGF对PCOS的预测价值。结果 PCOS组血清IGFBP-3水平低于对照组（P <0.05），PDGF、bFGF水平均高于对照组（P <0.05）。妊娠结局不良组血清IGFBP-3水平低于妊娠结局良好组（P <0.05），PDGF、bFGF水平均高于妊娠结局良好组（P <0.05）。ROC曲线分析结果显示，血清IGFBP-3、PDGF、bFGF水平预测PCOS患者妊娠结局的敏感性分别为80.60%、74.20%和71.00%，特异性分别为81.50%、82.40%和73.10%，ROC曲线下面积（AUC）分别为0.828、0.804和0.754；三者联合检测的敏感性为90.30%，特异性为80.70%，AUC为0.938。结论 PCOS患者血清IGFBP-3水平降低，PDGF、bFGF水平升高，且妊娠结局不良组血清IGFBP-3水平降低，PDGF、bFGF水平升高，提示血清IGFBP-3、PDGF、bFGF与PCOS疾病的发生发展密切相关，可作为预测PCOS患者妊娠结局的评估指标。

Abstract:

Objective To explore the predictive value of combined serum insulin-like growth factor binding protein-3 (IGFBP-3), platelet-derived growth factor (PDGF), and basic fibroblast growth factor (bFGF) levels for pregnancy outcomes in patients with polycystic ovary syndrome (PCOS).Methods A total of 150 pregnant women with PCOS treated at Cangzhou Central Hospital from May 2021 to December 2022 were selected as the PCOS group, and 90 pregnant women undergoing prenatal examinations during the same period were selected as the control group. Serum IGFBP-3, PDGF, and bFGF levels were compared between the two groups. The PCOS group was further divided into a good pregnancy outcome group (n = 119) and a poor pregnancy outcome group (n = 31) based on pregnancy outcomes. Pregnancy outcomes of PCOS patients were assessed, and serum IGFBP-3, PDGF, and bFGF levels were compared. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive value of serum IGFBP-3, PDGF, and bFGF for PCOS.Results Serum IGFBP-3 levels in the PCOS group were lower than those in the control group (P < 0.05), while PDGF and bFGF levels were higher (P < 0.05). In the poor pregnancy outcome group, serum IGFBP-3 levels were lower than in the good pregnancy outcome group (P < 0.05), and PDGF and bFGF levels were higher (P < 0.05). ROC curve analysis showed that serum IGFBP-3, PDGF, and bFGF levels had sensitivities of 80.60%, 74.20%, and 71.00%, specificities of 81.50%, 82.40%, and 73.10%, and areas under the ROC curve (AUC) of 0.828, 0.804, and 0.754, respectively, for predicting pregnancy outcomes in PCOS patients. Combined detection of the three markers yielded a sensitivity of 90.30%, specificity of 80.70%, and an AUC of 0.938.Conclusion PCOS patients exhibit decreased serum IGFBP-3 levels and increased PDGF and bFGF levels. In the group with poor pregnancy outcomes, serum IGFBP-3 levels are lower, and PDGF and bFGF levels are higher. This suggests that serum IGFBP-3, PDGF, and bFGF are closely related to the occurrence and development of PCOS and can serve as evaluation indicators for predicting pregnancy outcomes in PCOS patients.