血脂波动性与心血管疾病的研究进展

Research progress of the correlation between lipid variability and cardiovascular diseases

摘要:

血脂异常在心血管疾病（CVD）的进程中起重要作用。血脂波动性是一项重要的新型评估参数。近年来，大量国内外研究证实，除了平均血脂水平之外，标准差、变异系数及与均值无关的波动性等指标评价的个体血脂参数的波动性与CVD不良健康结局独立相关，维持血脂长期稳定的管理策略在延缓疾病进程中起着关键作用。该综述旨在总结血脂参数的波动性在CVD相关的研究进展及其在临床诊断和管理决策中的应用价值。

Abstract:

Dyslipidemia is a significant factor in the progression of cardiovascular diseases (CVD). Recent studies have shown that lipid fluctuations are linked to unfavorable clinical outcomes, highlighting the importance of long-term stable lipid management strategies in delaying the disease process. Moreover, lipid variability has emerged as an important new assessment parameter. Apart from mean lipid levels, the correlation between individual blood lipid variation and CVD,evaluated by metrics such as standard deviation (SD), coefficient of variation (CV), and variability independent of the mean (VIM), has been well confirmed. This review aims to summarize the research progress on the variability of blood lipid parameters in CVD. The review also highlights the clinical significance of these parameters in the diagnosis and management of these diseases.