内皮细胞活化在血栓闭塞性脉管炎中的机制研究进展

Advances in the mechanism of endothelial cell activation in thromboangiitis obliterans

摘要:

血栓闭塞性脉管炎（TAO）是一种主要影响四肢中小血管的炎症性血管疾病，内皮细胞活化在该病的发生、发展中起关键作用。免疫复合物的沉积、高滴度的炎症免疫细胞和炎症细胞因子、诱导型一氧化氮合酶过表达、氧化应激反应、内质网应激、线粒体功能障碍、铜稳态、铁代谢、糖酵解等生理、病理过程都会促使内皮细胞活化而参与到TAO的病理进程中，因此掌握其分子机制，减轻内皮细胞活化或损伤是治疗TAO疾病的关键。

Abstract:

Thromboangiitis obliterans (TAO) is an inflammatory vascular disease that primarily affects small and medium-sized blood vessels in the extremities, and endothelial cell activation plays a key role in the development of the disease. Various physiopathological processes such as immune complex deposition, high levels of inflammatory immune cells and inflammatory cytokines, overexpression of inducible nitric oxide synthase (iNOS), oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, copper homeostasis, iron metabolism, and glycolysis all promote endothelial cell activation and are involved in the pathogenesis of TAO. Thus, understanding these molecular mechanisms to develop strategies for mitigating endothelial cell activation or injury is crucial for the treatment of TAO.