慢性阻塞性肺疾病与Hedgehog信号通路关系的研究进展

Advances in the relationship between chronic obstructive pulmonary disease and the Hedgehog signaling pathway

摘要:

慢性阻塞性肺疾病（COPD）是一种以气流阻塞为特征的疾病，患病率、病死率较高。刺猬（HH）信号通路在调节控制机体组织形态发育及损伤修复中发挥关键作用。研究发现COPD与HH信号通路密切相关，在气道受损发生炎症反应时，该通路中的一些重要的信号分子可以改善炎症和纤维化。深入了解HH信号通路在COPD发生、发展过程中的作用，将有利于进一步发现和研究该疾病的治疗靶点。该综述通过介绍HH通路和重要信号分子影响肺的发育和调控COPD炎症反应，对COPD病理、生理过程具有重要意义，为HH信号通路治疗COPD提供理论依据。

Abstract:

Chronic obstructive pulmonary disease (COPD) is a disease characterized by airflow obstruction, with high prevalence and mortality rates. The Hedgehog (HH) signaling pathway plays a key role in regulating and controlling the morphology and development of tissues and the damage repair. It has been found that COPD is closely related to the HH signaling pathway, and that some important signaling molecules in this pathway can ameliorate inflammation and fibrosis when airway impairment induces inflammatory responses. An in-depth understanding of the roles of the HH signaling pathway in the development of COPD will facilitate further discovery and research into therapeutic targets for this disease. By introducing the HH pathway and critical signaling molecules affecting the lung development and regulating inflammatory responses in COPD, this review is of great significance for gaining insights into the pathophysiological processes of COPD, and provides a theoretical basis for the treatment of COPD by targeting the HH signaling pathway.