雌激素联合保妇康栓治疗绝经后宫颈人乳头瘤病毒感染的临床疗效分析

Clinical efficacy of estrogen combined with Baofukang suppository in the treatment of cervical HPV infection in postmenopausal women

摘要:

目的 研究雌激素联合保妇康栓治疗绝经后宫颈人乳头瘤病毒（HPV）感染的临床疗效。方法 选取2019年2月—2022年7月无锡市第九人民医院收治的89例绝经后宫颈HPV感染患者，按治疗方法不同分为研究组（46例）和对照组（43例）。对照组接受雌激素治疗，研究组在对照组基础上接受保妇康栓治疗。两组均持续治疗3个月。对比两组异常分泌物持续时间、HPV转阴时间、临床疗效、炎症因子、免疫功能、液基薄层细胞学检查（LCT）评分与宫颈炎症评分及不良反应。结果 研究组异常分泌物持续时间、HPV转阴时间均短于对照组（P <0.05）。研究组总有效率高于对照组（P <0.05）。研究组治疗前后白细胞介素-4、γ干扰素、白细胞介素-2、肿瘤坏死因子-α的差值均高于对照组（P <0.05）。研究组治疗前后CD3⁺、CD19⁺、CD3⁺CD8⁺、CD3^-CD56⁺的差值均高于对照组（P <0.05）。研究组治疗前后LCT评分、宫颈炎症评分的差值均高于对照组（P <0.05）。两组不良反应总发生率比较，差异无统计学意义（P >0.05）。结论 雌激素联合保妇康栓治疗绝经后宫颈HPV感染疗效确切，可加快HPV转阴，改善患者免疫功能，减轻宫颈炎症反应，且安全可靠。

Abstract:

Objective To study the clinical efficacy of estrogen combined with Baofukang suppository in the treatment of cervical human papillomavirus (HPV) infection in postmenopausal women.Methods A total of 89 postmenopausal patients with cervical HPV infection admitted to our hospital from February 2019 to July 2022 were selected and divided into study group (n = 46) and control group (n = 43) according to different treatment methods. The control group received estrogen therapy, and the study group received Baofukang suppository therapy on the basis of the estrogen therapy. Both groups were treated for 3 months. The duration of abnormal discharge, time to negative conversion of HPV, clinical efficacy, inflammatory factors, immune function, LCT score, cervical inflammation score and adverse reactions were compared between the two groups.Results The duration of abnormal discharge and the time to negative conversion of HPV in the study group were shorter than those in the control group (P < 0.05). The overall effective rate of the study group was higher than that of the control group (P < 0.05). The differences of interleukin-4 (IL-4), interferon-γ (IFN-γ), interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) before and after treatment in the study group were higher than those in the control group (P < 0.05). The differences of the frequency of CD3⁺, CD19⁺, CD3⁺ CD8⁺ and CD3^-CD56⁺ cells before and after treatment in the study group were higher than those in the control group (P < 0.05). The differences of the LCT score and the cervical inflammation score before and after treatment in the study group were higher than those in the control group (P < 0.05). There was no significant difference in the overall incidence of adverse reactions between the two groups (P > 0.05).Conclusions Estrogen combined with Baofukang suppository is effective in the treatment of cervical HPV infection in postmenopausal women, by promoting the negative conversion of HPV, improving the immune function of patients, and reducing cervical inflammation with being safe and reliable.