胸腔镜肺楔形切除术对小于1.5 cm肺混合性磨玻璃结节患者疗效及血清NOX2水平的影响

Therapeutic efficacy of thoracoscopic wedge resection for pulmonary mixed ground glass nodules smaller than 1.5 cm and its effects on the serum level of NOX2

摘要:

目的 探究胸腔镜肺楔形切除术对小于1.5 cm肺混合性磨玻璃结节（GGN）患者疗效及血清还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶2（NOX2）水平的影响。方法 选取2018年11月—2022年11月安徽医科大学第二附属医院收治的96例肺混合性GGN患者，利用随机数字表法分为对照组（48例，采用胸腔镜下肺叶切除术进行治疗）与研究组（48例，采用胸腔镜肺楔形切除术进行治疗）。比较两组肺患者的临床疗效、手术指标、肺功能、血清NOX2水平的变化及术后发生并发症的情况。结果 研究组总有效率高于对照组（P <0.05）。研究组术中出血量低于对照组（P <0.05），手术时间、胸管留置时间、住院时间短于对照组（P <0.05）。研究组治疗前后最大肺活量、每分钟最大通气量、残气量的差值高于对照组（P <0.05）。研究组手术前后血清NOX2的差值低于对照组（P <0.05）。两组患者术后并发症总发生率比较，差异无统计学意义（P >0.05）。结论 胸腔镜肺楔形切除术治疗肺混合性GGN的疗效确切，可改善患者的手术指标及肺功能，降低患者血清NOX2水平，安全性高，值得推广。

Abstract:

Objective To investigate the therapeutic efficacy of thoracoscopic wedge resection for pulmonary mixed ground glass nodules (GGN) smaller than 1.5 cm and its effects on the serum level of nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2).Methods From November 2018 to November 2022, a total of 96 patients with pulmonary mixed GGN admitted to our hospital were selected and randomly grouped into the control group (48 cases, treated with thoracoscopic lobectomy) and the study group (48 cases, treated with thoracoscopic pulmonary wedge resection). The clinical efficacy, surgery-related indicators, lung function, changes in the serum level of NOX2, and postoperative complications of the two groups were compared.Results Compared with the control group, the overall effective rate of the study group was higher (P < 0.05). The intraoperative blood loss of the study group was less than that of the control group (P < 0.05), while the operative duration, the dwelling time of the intrathoracic catheter, and the length of hospital stay of the study group were shorter than those of the control group (P < 0.05). The differences of forced vital capacity (FVC), maximal voluntary ventilation (MVV) and residual volume (RV) before and after the treatment in the study group were higher than those in the control group (P < 0.05). The difference of the serum level of NOX2 before and after the surgery in the study group was higher than that in the control group (P < 0.05). There was no significant difference in the overall incidence of postoperative complications between the two groups (P > 0.05).Conclusions Thoracoscopic wedge resection is effective in the treatment of pulmonary mixed GGN. It can improve the surgery-related indicators and lung function of patients, and reduce the serum level of NOX2 in patients with good safety. Thus, it is worth popularizing.