根管治疗中Vitapex糊剂与奥硝唑碘仿糊剂对窦道型根尖周炎的疗效比较

Comparison of curative effect of Vitapex paste and Ornidazole iodoform paste on sinus type periapical inflammation in root canal treatment

摘要:

目的 分析根管治疗中Vitapex糊剂与奥硝唑碘仿糊剂对窦道型根尖周炎疗效的影响。方法 选取2019年1月—2022年2月青岛大学附属青岛市海慈医院收治的118例窦道型根尖周炎患者，以随机数字表法分为研究组和对照组，各59例。两组均进行根管治疗，对照组充填奥硝唑碘仿糊剂，研究组充填Vitapex糊剂，治疗后随访6个月。比较两组充填治疗后的疼痛反应、窦道愈合情况、根尖愈合情况、综合疗效及牙周炎症因子（高敏C反应蛋白、白细胞介素-6、白细胞介素-8）水平。结果 两组充填治疗后疼痛反应发生率比较，差异无统计学意义（P >0.05）。研究组窦道愈合率高于对照组（P <0.05）。两组治疗前、治疗3个月、治疗6个月的根尖透射区面积比较，采用重复测量设计的方差分析，结果 ①不同时间点的根尖透射区面积有差异（P <0.05）；②两组的根尖透射区面积有差别（P <0.05），研究组治疗3个月、治疗6个月的根尖透射区面积均低于对照组；③两组根尖透射区面积的变化趋势有差异（P <0.05）。研究组的成功率高于对照组（P <0.05）。研究组治疗前后的高敏C反应蛋白、白细胞介素-6、白细胞介素-8差值均高于对照组（P <0.05）。结论 与奥硝唑碘仿糊剂比较，Vitapex糊剂对窦道型根尖周炎患者根管治疗的窦道愈合、根尖愈合及减轻牙周炎症反应方面更具优势，综合治疗效果更佳。

Abstract:

Objective To analyze the impact of Vitapex paste and metronidazole iodine paste on the efficacy of root canal treatment in patients with sinus tract-type apical periodontitis.Methods A total of 118 patients diagnosed with sinus tract-type apical periodontitis at Qingdao Hai Ci Hospital affiliated with Qingdao University from January 2019 to February 2022 were selected. Using a random number table, the patients were divided into a study group and a control group, with 59 patients in each group. Both groups underwent root canal treatment, with the control group filled with metronidazole iodine paste and the study group filled with Vitapex paste. Follow-up was conducted for 6 months after treatment. The post-filling pain reaction, sinus tract healing, apical healing, comprehensive efficacy, and levels of periodontal inflammatory factors (high-sensitivity C-reactive protein, interleukin-6, interleukin-8) were compared between the two groups.Results The incidence of post-filling pain reactions was comparable between the two groups (P > 0.05). The study group showed a higher sinus tract healing rate than the control group (P < 0.05). The root apex transparency area at different time points showed differences (P < 0.05) and the study group had a lower root apex transparency area at 3 and 6 months compared to the control group (P < 0.05). The change trend in the root apex transparency area differed between the two groups (P < 0.05). The success rate in the study group was higher than in the control group (P < 0.05). The changes in high-sensitivity C-reactive protein, interleukin-6, and interleukin-8 values before and after treatment were higher in the study group than in the control group (P < 0.05).Conclusion Compared to metronidazole iodine paste, Vitapex paste demonstrated superior advantages in sinus tract healing, apical healing, and reduction of periodontal inflammatory responses in patients with sinus tract-type apical periodontitis undergoing root canal treatment. The overall treatment effect was better with Vitapex paste.