脂联素调节肺部炎症的研究进展

Research progress on the regulatory roles of adiponectin in pulmonary inflammation

摘要:

炎症是很多肺部常见疾病如肺炎、慢性阻塞性肺疾病、哮喘等共同病理学、生理学基础，炎症消退反应的发生机制将为治疗肺部炎症性疾病提供新方向。脂联素是一种主要由脂肪细胞生成和分泌的蛋白质激素，具有调节炎症的作用，在许多炎症性疾病中发挥保护性作用。近期有研究发现，脂联素的信号受体AdipoR1和AdipoR2在肺细胞中表达，对肺生理学具有功能作用，并在慢性阻塞性肺病、哮喘和侵袭性真菌感染中发挥抗炎活性。该文将结合近期的研究工作对脂联素在肺部炎症性疾病中的作用机制进行综述，以期为肺部炎症性疾病的治疗提供参考依据与临床意义。

Abstract:

Inflammation serves as the common pathophysiological foundation for numerous prevalent lung diseases, including pneumonia, chronic obstructive pulmonary disease (COPD), asthma, and others. Understanding the mechanism underlying the resolution of inflammation may pave the way for novel therapeutic approaches in managing pulmonary inflammatory disorders. Adiponectin, a protein hormone produced and secreted mainly by adipocytes, exerts regulatory effects on inflammation and exhibits protective properties against various inflammatory diseases. Recent studies have shown that adiponectin signaling receptors AdipoR1 and AdipoR2 are expressed by lung cells, actively participate in lung physiology, and exert anti-inflammatory activities in COPD, asthma, as well as invasive fungal infections. This review summarizes recent studies exploring the roles of adiponectin in pulmonary inflammatory diseases, aiming to provide clinical insights for the treatment of pulmonary inflammatory diseases.