首页 > 过刊浏览>2024年第34卷第13期 >57-62. DOI:10.3969/j.issn.1005-8982.2024.13.008
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Tfh/Tfr细胞免疫平衡在血液恶性肿瘤中的研究进展
作者:
作者单位:

新疆医科大学第一附属医院 血液病中心(新疆维吾尔自治区血液病研究所)， 新疆 乌鲁木齐 830054

通讯作者:

曲建华，E-mail：jhuaqu@163.com；Tel：13199855506

中图分类号:

R733

基金项目:

国家自然科学基金（No：82160034）；新疆维吾尔自治区天山创新团队项目（No：2022D14008）


Research progress on Tfh/Tfr cell immune balance in hematologic malignancies
Author:
Affiliation:

The First Affiliated Hospital of Xinjiang Medical University (Institute of Hematology of Xinjiang Uygur Autonomous region) Urumqi, Xinjiang 830054, China

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    摘要:

    滤泡辅助性T细胞（Tfh）和滤泡调节性T细胞（Tfr）是新发现的具有相互拮抗作用的CD4+T细胞亚群。在淋巴结生发中心发挥功能和体液免疫形成过程中，Tfh细胞辅助浆细胞的抗体生成，而Tfr细胞具有抑制Tfh细胞和B细胞功能。Tfh/Tfr细胞免疫平衡对维持生发中心的形成、诱导B细胞成熟及抗体的产生等具有十分重要的意义。Tfh/Tfr细胞平衡与自身免疫疾病、实体肿瘤及部分血液系统疾病的进展密切相关，而其在血液恶性肿瘤中的作用尚不清楚。该文就Tfh/Tfr细胞的免疫平衡紊乱在血液恶性肿瘤中的最新研究进展进行综述，为恶性血液肿瘤的发病机制和免疫治疗指明新的方向。

    Abstract:

    Follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr) are newly discovered CD4+ T cell subsets with opposite effects. In the process of germinal center and humoral immunity, Tfh cells assist in the production of antibodies, while Tfr cells inhibit the function of Tfh cells and B cells. The immune balance of Tfh/Tfr cells plays an important role in the formation of germinal center, the proliferation and differentiation of B cells and the production of antibodies. Tfh/Tfr cell balance is closely related to autoimmune diseases, solid tumors and some hematological diseases, but its role in malignant hematological tumors is not clear. This paper reviews the latest research progress of Tfh/Tfr cell immune balance in malignant hematological tumors, which points out a new direction for the pathogenesis and immunotherapy of malignant hematological tumors.

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张冉冉,张瑞,曲建华. Tfh/Tfr细胞免疫平衡在血液恶性肿瘤中的研究进展[J].中国现代医学杂志,2024,34(13):57-62

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  • 收稿日期:2024-01-04
  • 在线发布日期: 2024-12-19
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