肠道微生物群与脓毒症心肌病相互作用的研究进展

Advances in research on gut microbiota in sepsis-induced cardiomyopathy

摘要:

脓毒症心肌病（SICM）是脓毒症的常见并发症，其发病机制尚不完全清楚。目前大量研究证明肠道微生态与多种心血管疾病相关，而少有研究报道肠道菌群对SICM的影响。近年来，有研究发现，除了已知的机制外，肠道微生物组失衡、黏膜屏障损伤、微生物易位、代谢失调、线粒体功能障碍及炎症反应可能通过肠-心轴或肠-肾-心轴影响SICM。该综述主要探讨了脓毒症期间肠道菌群与SICM的潜在联系，更好地了解这一机制将有助于改善脓毒症的治疗，并使脓毒症患者获得更好的预后。

Abstract:

Sepsis-induced cardiomyopathy (SICM) represents a frequent sepsis complication, with its underlying mechanisms remain incompletely understood. Extensive research has established the gut microbiota's association with various cardiovascular diseases; however, insights into its impact on SICM remain limited. Recent investigations beyond established mechanisms have identified potential influences on SICM through the gut-heart or gut-kidney-heart axis, including dysbiosis of the gut microbiome, impairment of the mucosal barrier, microbial translocation, metabolic dysregulation, mitochondrial dysfunction, and inflammatory responses. This review aims to delve into the potential interplay between gut microbiota alterations during sepsis and SICM. Enhancing our understanding of these connections could pave the way for improved therapeutic approaches to sepsis and better prognoses for affected individuals.