西藏门巴族人群胰岛细胞功能、脂质代谢、炎症反应与中医体质的相关性研究

Study on the correlation between the function of islet cells, lipid metabolism, inflammatory reaction and the constitution of traditional Chinese medicine in Tibetan Menba people

摘要:

目的 探讨西藏门巴族人群胰岛细胞功能、脂质代谢和炎症反应与中医体质的相关性。方法 选取2023年1月—2023年6月墨脱村、亚东村、朗杰岗村、巴日村、德吉村、玛迪村6个门巴族乡的门巴族人群进行调查，共计237例。分析人群中医体质分布情况，同时比较前三位中医体质人群的胰岛细胞功能、脂质代谢和炎症因子水平。结果 中医体质类型中以痰湿质、湿热质和气虚质为主，分别占32.07%、26.16%和18.57%。痰湿质组、湿热质组和气虚质组性别、年龄、体质量指数比较，差异均无统计学意义（P >0.05）。湿热质组空腹血糖和胰岛素抵抗指数分别为（4.98±0.83）mmol/L和（1.75±0.32），均低于痰湿质组和气虚质组（P <0.05），湿热质组胰岛β细胞功能指数为（94.45±9.11），均高于痰湿质和气虚质组（P <0.05）；湿热质组总胆固醇和甘油三酯分别为（3.98±0.99）mmol/L和（1.02±0.29）mmol/L，均低于痰湿质组和气虚质组（P <0.05），湿热质组高密度脂蛋白胆固醇为（1.26±0.20）mmol/L，均高于痰湿质组和气虚质组（P <0.05）。痰湿质、湿热质和气虚质组血清白细胞介素-6、超敏c反应蛋白、肿瘤坏死因子-α比较，差异均无统计学意义（P >0.05）。结论 西藏门巴族人群中医体质以痰湿质、湿热质和气虚质为主，其中湿热质人群胰岛细胞功能、脂质代谢优于痰湿质和气虚质人群，炎症因子比较无差异。

Abstract:

Objective To explore the correlation between islet cell function, lipid metabolism, inflammatory response, and traditional Chinese medicine (TCM) constitution in the Xizang Menba ethnic group.Methods From Januaryto June 2023, a total of 237 people were selected from 6 Menba villages, including Motuo Village, Yadong Village, Langjie Gang Village, Bari Village, Deji Village and Madi Village. The distribution of TCM constitution of the population were analyzed, and the top three people of Chinese medicine constitution were selected to compare the differences in islet cell function, lipid metabolism and inflammatory factor level and so on.Results The main types of TCM constitution arephlegm-dampness, damp-heat and qi-deficiency, accounting for 32.07%, 26.16% and 18.57% respectively.There was no significant difference in sex, age and body mass index between the phlegm-dampness, damp-heat and qi-deficiency groups (P > 0.05).The fasting blood glucose and insulin resistance index (HOMA-IR) in the damp-heat group were (4.98 ± 0.83) mmol/L and (1.75 ± 0.32), respectively, which were significantly lower than those in the phlegm-dampnessand qi-deficiency groups (P < 0.05), while HOMA - β was (94.45 ± 9.11), which was higher than those in the phlegm-dampnessand qi-deficiency groups (P < 0.05).The total cholesterol (TC) and triglyceride (TG)in the damp-heatgroup were (3.98 ± 0.99) mmol/L and (1.02 ± 0.29) mmol/L, respectively , which were lower than those in the group of phlegm-dampnessand qi-deficiency (P < 0.05), while high-density lipoprotein cholesterol (HDL-C) was (1.26 ± 0.20) mmol/L, which was higher than that of thephlegm-dampnessand qi-deficiencygroups (P < 0.05).There was no statistically significant difference in serum interleukin - 6 (IL - 6), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) among the phlegm-dampness, damp-heat and qi-deficiency groups (P > 0.05).Conclusion The traditional Chinese medicine constitution of Xizang Menba people is dominated by phlegm-dampness, damp-heat and qi-deficiency. Among them, the function of islet cells and lipid metabolism of damp-heat people are better than those of qi-deficiency and yang-deficiency people, and there is no significant difference in inflammatory factors.