奥美拉唑联合阿托品对急性胃炎患者血清胃泌素和丙二醛水平的影响

Effects of omeprazole combined with atropine on serum gastrin and malondialdehyde levels in patients with acute gastritis

摘要:

目的 探讨奥美拉唑联合阿托品对急性胃炎患者血清胃泌素和丙二醛水平的影响。方法 选取2020年1月—2023年1月大庆龙南医院收治的107例急性胃炎患者为研究对象，按治疗方法分为对照组（53例）和观察组（54例）。对照组采用奥美拉唑联合山莨菪碱治疗，观察组采用奥美拉唑联合阿托品治疗，两治疗持续14 d。比较两组的临床疗效、血清胃泌素水平、丙二醛水平、血清胃蛋白酶原I水平、药物耐受情况、消化不良症状积分、炎症因子［白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）］水平，并记录两组患者的不良反应发生率。结果 观察组治疗总有效率高于对照组（P <0.05）。观察组治疗前后血清胃泌素、丙二醛及血清胃蛋白酶原I水平的差值均高于对照组（P <0.05）。两组药物耐受情况比较，差异无统计学意义（P >0.05）。观察组治疗前后嗳气、恶心呕吐、早饱感、上腹部灼烧感及上腹胀痛的不良症状积分的差值均高于对照组（P <0.05）。观察组治疗前后IL-6、TNF-α和CRP水平的差值均高于对照组（P <0.05）。两组不良反应发生率比较，差异无统计学意义（P >0.05）。结论 奥美拉唑联合阿托品对急性胃炎患者的血清胃泌素和丙二醛水平有明显的降低作用，并能有效改善患者的临床症状和降低炎症因子水平，对调节急性胃炎患者的血清指标具有良好的疗效，可能成为治疗急性胃炎的新策略。

Abstract:

Objective To explore the effects of omeprazole combined with atropine on serum gastrin and malondialdehyde levels in patients with acute gastritis.Method This study included 107 patients with acute gastritis treated in our hospital from January 2020 to January 2023. Divided into a control group (53 cases, treated with omeprazole combined with scopolamine) and an observation group (54 cases, treated with omeprazole combined with atropine), the treatment lasted for 14 days. Evaluate the clinical treatment efficacy, serum gastrin levels, malondialdehyde levels, serum pepsinogen I levels, drug tolerance, score of digestive symptoms, inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] in two groups of patients, C-reactive protein (CRP) levels were measured, and the incidence of adverse reactions was recorded for both groups of patients.Result The total effective rate of the observation group was higher than that of the control group (P < 0.05). The difference before and after malondialdehyde treatment, and the difference before and after serum pepsinogen I treatment also showed that the difference was statistically significant (P < 0.05), and the difference in these indicators before and after treatment in the observation group was lower than that in the control group. In the comparison of drug tolerance, did not show statistical significance (P > 0.05); In addition, the difference in the scores of adverse symptoms such as belching, nausea and vomiting, early satiety, upper abdominal burning sensation, and upper abdominal distension before and after treatment between the two groups was statistically significant (P <0.05). The difference in the scores of various digestive symptoms before and after treatment in the observation group was higher than that in the control group (P < 0.05). The observation group had IL-6 and TNF-α before and after treatment. The difference between CRP and the control group was higher (P < 0.05). The incidence of adverse reactions between the two groups was compared, did not show statistical significance (P > 0.05).Conclusion The combination of omeprazole and atropine has a significant reducing effect on serum gastrin and malondialdehyde levels in patients with acute gastritis, and can effectively improve clinical symptoms and reduce levels of inflammatory factors. It shows good therapeutic effect on regulating serum indicators in patients with acute gastritis and may become a new strategy for treating acute gastritis.