成纤维细胞在瘢痕疙瘩发病机制中的研究进展

Research progress on the role of fibroblasts in the pathogenesis of keloids

摘要:

成纤维细胞作为主要的结缔组织细胞，通过过度生产细胞外基质（ECM）、抑制ECM降解、向肌成纤维细胞的转化，以及与炎症因子和免疫细胞之间的复杂相互作用等，在瘢痕疙瘩的形成、发展中发挥重要作用。该文通过总结成纤维细胞在瘢痕疙瘩发病机制关键过程中的角色，为瘢痕疙瘩的治疗提供新的思路和策略。

Abstract:

Fibroblasts, as the primary connective tissue cells, play a crucial role in the formation and development of keloids through the excessive production of the extracellular matrix (ECM), inhibition of ECM degradation, transformation into myofibroblasts, and complex interactions with inflammatory factors and immune cells. This review summarizes the role of fibroblasts in key processes of the pathogenesis of keloids, providing novel insights and strategies for the treatment of keloids.