单尖充填技术联合新型生物陶瓷iRoot BP Plus治疗慢性根尖周炎的临床研究

Clinical study on the efficacy of single-point filling technique combined with novel bioceramic iRoot BP plus in the treatment of chronic apical periodontitis

摘要:

目的 探讨单尖充填技术联合新型生物陶瓷iRoot BP Plus治疗慢性根尖周炎的临床效果。方法 回顾性分析2022年3月—2023年6月在常州市武进中医医院就诊的87例慢性根尖周炎患者的临床资料。根据不同治疗方法分为观察组44例和对照组43例。对照组采用AH Plus联合热牙胶垂直加压技术治疗，观察组采用新型生物陶瓷iRoot BP Plus联合单尖充填技术治疗。比较两组急症反应程度、临床疗效、咀嚼功能、龈沟液血清学指标、治疗满意度及并发症。结果 观察组急症反应程度等级优于对照组（P <0.05）。观察组临床疗效等级优于对照组（P <0.05）。观察组手术前后咀嚼力、咀嚼效率的差值高于对照组（P <0.05），且观察组比对照组高（P <0.05）。观察组手术前后龈沟液碱性成纤维细胞生长因子（bFGF）、血管内皮生长因子（VEGF）、基质金属蛋白酶抑制剂-1（TIMP-1）水平均高于对照组（P <0.05）。观察组后期指导、医疗环境、康复情况、医疗服务满意度高于对照组（P <0.05）。观察组并发症总发生率低于对照组（P <0.05）。结论 单尖充填技术联合新型生物陶瓷iRoot BP Plus治疗慢性根尖周炎疗效显著，可减轻急症反应程度与龈沟液炎症反应，调节生长因子失衡，改善咀嚼功能，提高治疗满意度，且可降低并发症发生风险。

Abstract:

Objective To investigate the clinical efficacy of the single-point filling technique combined with the novel bioceramic material iRoot BP Plus in the treatment of chronic apical periodontitis.Methods A retrospective analysis was conducted on 87 patients with chronic apical periodontitis treated at Wujin Traditional Chinese Medicine Hospital from March 2022 to June 2023. The patients were divided into two groups based on treatment methods: the observation group (44 cases) and the control group (43 cases). The control group received treatment with AH Plus and vertical condensation of gutta-percha, while the observation group was treated with iRoot BP Plus combined with the single-point filling technique. The following were compared between the two groups: emergency response severity, clinical efficacy, chewing function, gingival crevicular fluid (GCF) serological markers, treatment satisfaction, and incidence of complications.Results The observation group showed better emergency response severity levels compared to the control group (P < 0.05). Clinical efficacy was also superior in the observation group (P < 0.05). The changes in chewing force and efficiency before and after surgery were greater in the observation group compared to the control group (P < 0.05). Additionally, the observation group had higher levels of basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and tissue inhibitor of metalloproteinases-1 (TIMP-1) in GCF before and after surgery compared to the control group (P < 0.05). Satisfaction with guidance, medical environment, rehabilitation, and medical services was higher in the observation group (P < 0.05). The incidence of complications was lower in the observation group compared to the control group (P < 0.05).Conclusion The single-point filling technique combined with novel bioceramic iRoot BP Plus demonstrates significant clinical efficacy in treating chronic apical periodontitis. It reduces emergency response severity and gingival crevicular fluid inflammation, balances growth factors, improves chewing function, enhances treatment satisfaction, and lowers the risk of complications.