急性髓系白血病中的铁死亡机制：潜在治疗靶点及新观点

Ferroptosis mechanisms in acute myeloid leukemia: potential therapeutic targets and novel perspective

摘要:

急性髓系白血病（AML）是一种血液系统恶性肿瘤，发病机制复杂，涉及多种基因和信号通路的异常。近年来，铁死亡作为一种新的细胞死亡方式，逐渐成为研究热点。该文综述铁死亡在AML中的研究进展，探讨铁死亡的机制、调控因素及与AML发生发展的关系，并讨论铁死亡作为治疗AML潜在靶点的可能性。研究表明，铁死亡在AML中发挥重要作用，通过调控铁代谢、氧化应激和细胞自噬等途径影响白血病细胞的生存和死亡。铁死亡的诱导可能成为治疗AML的新策略，为开发新的治疗手段提供理论支持。然而，目前对铁死亡在AML中的具体作用机制仍不完全清楚，需要深入探讨。同时，如何有效地诱导铁死亡而不引起正常细胞的损伤，也是未来研究中需要解决的关键问题。因此，对铁死亡的深入研究将有助于更好地理解AML的发病机制，并为开发新的治疗手段提供更多可能性。

关键词:急性髓系白血病;铁死亡;脂质代谢;活性氧;铁代谢

Abstract:

Acute myeloid leukemia (AML) is a hematologic malignancy with a complex pathogenesis involving the dysregulation of multiple genes and signaling pathways. In recent years, ferroptosis, as a novel form of regulated cell death, has become a research hotspot. This review summarizes the research progress on ferroptosis in AML, exploring the mechanisms, regulatory factors, and its role in the onset and progression of AML, while discussing the potential of ferroptosis as a therapeutic target for AML. Current studies indicate that ferroptosis plays a pivotal role in AML by modulating pathways such as iron metabolism, oxidative stress, and autophagy, thereby influencing the survival and death of leukemic cells. The induction of ferroptosis might represent a novel therapeutic strategy for AML, providing theoretical support for the development of new treatment approaches. However, the precise role of ferroptosis in AML remains unclear and requires further investigation. Additionally, how to effectively induce ferroptosis without damaging normal cells is a critical challenge that must be addressed in future research. Therefore, in-depth studies on ferroptosis are expected to enhance the understanding of AML pathogenesis and offer new possibilities for therapeutic interventions.

Key words:acute myeloid leukemia;ferroptosis;lipid metabolism;reactive oxygen species;iron metabolism