重组人干扰素α2b联合1，6-二磷酸果糖对轮状病毒肠炎患儿胃肠激素及炎症因子水平的影响

Effects of recombinant human interferon α2b combined with fructose-1,6-bisphosphate on levels of gastrointestinal hormones and inflammatory factors in children with rotavirus enteritis

摘要:

目的 探究重组人干扰素α2b联合1，6-二磷酸果糖对轮状病毒肠炎患儿的胃肠激素及炎症因子水平的影响。方法 前瞻性选取2018年6月—2023年6月邯郸市妇幼保健院接收的100例轮状病毒肠炎患儿，按信封抽签法随机分为单一组和联合组，每组50例。单一组给予重组人干扰素α2b，联合组给予重组人干扰素α2b联合1，6-二磷酸果糖。比较两组症状改善情况和治疗前后的胃肠激素、心肌酶谱、免疫球蛋白及炎症因子水平。结果 联合组的退热时间、止吐时间、大便恢复正常时间、脱水纠正时间均低于单一组（P <0.05）。联合组治疗前后胃泌素、胃动素、血管活性肠肽、乳酸脱氢酶、肌酸激酶同工酶MB、肌酸激酶、免疫球蛋白A、免疫球蛋白G、免疫球蛋白M、白细胞介素-17、白细胞介素-35、肿瘤坏死因子-α的差值均高于单一组（P <0.05）。结论 重组人干扰素α2b联合1，6-二磷酸果糖对轮状病毒肠炎患儿胃肠激素及炎症因子水平的影响较为显著。

Abstract:

Objective To explore the effects of recombinant human interferon α2b combined with fructose-1,6-bisphosphate on the levels of gastrointestinal hormones and inflammatory factors in children with rotavirus enteritis.Methods A total of 100 children with rotavirus enteritis admitted to the Handan Maternal and Child Health Hospital from June 2018 to June 2023 were prospectively selected, and they were randomly divided into a single group and a combined group, with 50 cases in each group. The single group was given recombinant human interferon α2b, and the combined group was given recombinant human interferon α2b plus fructose-1,6-bisphosphate. The improvement of symptoms and the levels of gastrointestinal hormones, myocardial enzymes, immunoglobulins and inflammatory factors before and after treatment were compared between the two groups.Results The combined group showed shorter time to resolution of fever, time to stop vomiting, time to normalize bowel movements, and time to dehydration correction compared with the single group (P < 0.05). In the combined group, the differences in levels of gastrin, motilin, vasoactive intestinal peptide, lactate dehydrogenase, creatine kinase isoenzyme MB, creatine kinase, immunoglobulin A, immunoglobulin G, immunoglobulin M, interleukin-17, interleukin-35, and tumor necrosis factor-alpha before and after treatment were greater than those in the single group (P < 0.05).Conclusions The combination of recombinant human interferon α2b and fructose-1,6-bisphosphate has a significant impact on the levels of gastrointestinal hormones and inflammatory factors in children with rotavirus enteritis.