非酒精性脂肪性肝病模型研究进展

Research progress on models of non-alcoholic fatty liver disease

摘要:

非酒精性脂肪性肝病（NAFLD）是指除长期大量饮酒等因素导致的以肝细胞内脂质过量堆积为主要特点的一种临床病理综合征。随着NAFLD在全球范围内发病率和患病率的逐年攀升，越来越多的研究聚焦在NAFLD发病机制上，但目前报道用于NAFLD机制研究的实验模型差异较大，尤其是动物模型。因此，该综述将总结近年来已报道的NAFLD研究模型，重点阐述NAFLD的动物模型和细胞模型，为NAFLD的研究者提供参考。

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is a clinical and pathological syndrome characterized by excessive lipid accumulation in hepatocytes, excluding other factors such as long-term excessive alcohol consumption. As the global incidence and prevalence of NAFLD continue to rise annually, increasing research has focused on the disease’s pathogenesis. However, the experimental models used for NAFLD research, particularly animal models, vary significantly. This review summarizes the recent progress in NAFLD research models, with a particular emphasis on animal and cell models, providing references for researchers studying NAFLD.