N6-甲基腺苷修饰及其在肺动脉高压中的研究进展

N6-methyladenosine modification and its roles in pulmonary hypertension

摘要:

N6-甲基腺苷（m6A）修饰是一种常见的RNA甲基化修饰，在许多的病理生理过程中起重要作用，与许多疾病的发生、发展密切相关，主要由甲基转移酶、去甲基化酶和m6A结合蛋白调节。肺动脉高压是一种常见的慢性呼吸系统疾病，且发病率较高，其主要病理特征是肺血管重塑，但发病机制尚不完全明确，并缺乏根治的方法。越来越多的证据表明，m6A修饰作为一种持续动态调节，可对肺动脉高压的特定基因表达和病理生理过程产生影响，参与肺动脉高压的发生、发展。通过对m6A修饰及其相关蛋白在肺动脉高压中的分子机制的研究，为肺动脉高压的治疗提供新思路和靶点。

Abstract:

N6-methyladenosine modification is one of the most prevalent forms of RNA methylation, which plays an important role in various pathophysiological processes and is closely associated with the onset and progression of numerous diseases. It is primarily regulated by methyltransferase, demethylase and m6A-binding protein. Pulmonary hypertension is a common chronic respiratory disease with a high morbidity. Pulmonary vascular remodeling is the main pathological feature of the disease. However, its underlying pathogenesis remains incompletely understood, and there is currently a lack of curative treatment options. An increasing body of evidence indicates that N6-methyladenosine modification, as a continuously dynamic regulatory mechanism, can influence the expression of specific genes and pathophysiological processes involved in pulmonary hypertension, thereby contributing to its onset and progression. Investigating the molecular mechanisms of N6-methyladenosine modification and its associated proteins in pulmonary hypertension may provide novel insights and potential therapeutic targets for the treatment of this disease.