代谢相关脂肪性肝病与慢性肾脏病的研究进展

Research advances in the relationship between metabolic dysfunction-associated fatty liver disease and chronic kidney disease

摘要:

代谢相关脂肪性肝病（MAFLD）是以肝内脂肪过度沉积为主要改变的一种慢性代谢功能障碍性肝损害，全球患病率逐年升高。目前越来越多的循证医学证据表明MAFLD与慢性肾脏病（CKD）关系密切。尽管两者间的机制尚未完全阐明，许多证据提示代谢功能障碍、肠道菌群失调、遗传学特征等在其中可能起到重要作用。该文综述了MAFLD与CKD关联的临床证据，MAFLD增加CKD风险的可能机制。

关键词:慢性肾脏病;代谢相关脂肪性肝病;研究进展

Abstract:

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic metabolic dysfunction-related liver injury characterized by excessive fat accumulation in the liver, and its global prevalence is increasing year by year. There is growing evidence of a strong association between MAFLD and chronic kidney disease (CKD). Although the mechanism between the two has not been fully elucidated, many studies indicate that metabolic dysfunction, gut microbiota imbalance, and genetic factors may play an important role. This review summarizes the clinical evidence of the association between MAFLD and CKD, and the possible mechanisms by which MAFLD increases the risk of CKD.

Key words:chronic kidney disease;metabolic dysfunction-associated fatty liver disease;research advances