时辰疗法：癌症个性化治疗新方向

Chronotherapy: A new direction in personalized therapy for cancer

摘要:

生物钟通过参与调节机体和细胞内各种生理代谢活动以维持体内稳态平衡。昼夜节律紊乱与癌症的发生、发展密切相关。生物钟基因在癌组织中的表达模式有异于正常组织。昼夜节律紊乱通过影响细胞周期、调节细胞凋亡等活动，加速癌细胞的增殖，促进癌症的发生、发展。由于昼夜节律在癌症进程扮演了重要角色，近年来，结合癌组织生理活动节律特点的时辰疗法得到广泛研究。该综述回顾了癌组织中分子生物钟的组成及作用，总结了癌症时辰疗法的现状，并归纳了前沿研究中个性化时辰疗法的生物标志物，旨在为高效精准的个性化癌症时辰疗法提供新思路。

Abstract:

The circadian clocks help maintain homeostasis by regulating various metabolic and biological processes within organisms and cells. Disturbances in the body's circadian rhythm have been associated with the development and progression of cancer. The expression patterns of clock genes in cancer tissues differ from those in normal tissues. Disruption of circadian rhythms accelerates cancer cell proliferation and promotes the occurrence and progression of cancer by affecting cell cycle, regulating apoptosis, and other events. Given the crucial role of circadian rhythms in cancer progression, chronotherapy, tailored to the physiological rhythms of cancer tissues, has been widely studied in recent years. This review explores the composition and function of molecular clocks in cancer tissues, summarizes the current state of cancer chronotherapy, and highlights biomarkers from cutting-edge research that may guide personalized chronotherapy, aiming to provide new insights for the development of highly effective and precise personalized cancer chronotherapy.