慢性肾病与脑小血管病的研究进展

Research progress of chronic kidney disease and cerebral small vessel disease

摘要:

慢性肾病是心脑血管疾病的危险因素之一。慢性肾病患者肾功能逐渐下降会引起广泛的生理、生物化学和血液学变化，这些变化同样也会影响脑小血管，进而引起脑小血管相关的疾病。该文就慢性肾病与脑小血管病相关联的机制、慢性肾病与脑小血管病亚型的相关性、慢性肾病与脑小血管病总负荷评分的关系，以及慢性肾病与认知功能障碍做一综述。

Abstract:

Chronic kidney disease (CKD) is a risk factor for cardiovascular and cerebrovascular diseases. The gradual decline in renal function in CKD patients leads to widespread physiological, biochemical, and hematological changes, which can also affect the cerebral small vessels and subsequently cause small vessel-related cerebral diseases. This review explores the mechanisms linking CKD to cerebral small vessel disease, the correlation between CKD and subtypes of cerebral small vessel disease, the relationship between CKD and total burden scores of cerebral small vessel disease, as well as the association between CKD and cognitive dysfunction.